From Murine to Human Nude/SCID: The Thymus, T-Cell Development and the Missing Link

Table 1

SCIDs classification. SCIDs have been so far classified according to the presence or absence of T, B, and NK cells, as a consequence of different molecular defects.

Lymphocyte phenotype	Gene defect	Form of SCID
T^−B^−NK^−	Adenylate kinase	Reticular dysgenesis
	Adenosine deaminase	ADA deficiency
T^−B^+NK^−	IL-2Rγ	SCID-X1
	Jak3	SCID-AR
T^−B^+NK^+	IL-7Rα	IL-7Rα deficiency
T^−B^−NK^+	Rag-1 or Rag-2 artemis	Omenn syndrome Artemis deficiency