Maternal Plasma Phosphatidylcholine Fatty Acids and Atopy and Wheeze in the Offspring at Age of 6 Years
Table 4
Relative risks (RR) for the association between standardised values (-scores) of maternal plasma PC fatty acids and wheeze phenotypes.
Transient wheeze
Persistent/late wheeze
Maternal exposure
Unadjusted analysis
Adjusted* analysis
Unadjusted analysis
Adjusted† analysis
RR
(95% CI)
RR
(95% CI)
RR
(95% CI)
RR
(95% CI)
Total -3 PUFAs %
0.94
(0.88, 1.02)
0.14
0.97
(0.90, 1.04)
0.40
0.85
(0.73, 0.99)
0.03
0.93
(0.79, 1.11)
0.44
ALA %
1.06
(0.98, 1.14)
0.13
1.06
(0.98, 1.14)
0.15
1.15
(1.01, 1.31)
0.04
1.09
(0.96, 1.24)
0.17
DHA %
0.92
(0.85, 1.00)
0.04
0.95
(0.88, 1.03)
0.19
0.81
(0.70, 0.95)
0.008
0.91
(0.76, 1.08)
0.28
EPA %
0.97
(0.90, 1.05)
0.51
0.98
(0.92, 1.06)
0.64
0.88
(0.72, 1.08)
0.22
0.91
(0.73, 1.14)
0.42
Total -6 PUFAs %
0.98
(0.91, 1.05)
0.58
0.97
(0.91, 1.04)
0.37
1.05
(0.91, 1.21)
0.52
0.99
(0.85, 1.16)
0.92
LA %
1.01
(0.94, 1.08)
0.84
1.00
(0.94, 1.08)
0.89
1.05
(0.91, 1.21)
0.49
1.04
(0.90, 1.21)
0.60
AA %
0.95
(0.89, 1.02)
0.19
0.94
(0.88, 1.02)
0.13
0.91
(0.79, 1.04)
0.16
0.88
(0.76, 1.02)
0.09
Total -3 : -6 PUFAs ratio
0.96
(0.89, 1.04)
0.29
0.98
(0.92, 1.05)
0.63
0.85
(0.73, 0.99)
0.04
0.94
(0.79, 1.12)
0.49
ALA: unsaturated metabolic products
1.09
(1.02, 1.17)
0.012
1.08
(1.01, 1.16)
0.03
1.21
(1.07, 1.36)
0.002
1.14
(1.01, 1.28)
0.03
LA: unsaturated metabolic products
1.01
(0.94, 1.09)
0.72
1.02
(0.95, 1.09)
0.61
1.02
(0.90, 1.16)
0.73
1.06
(0.93, 1.21)
0.42
Children with transient and persistent/late wheeze were compared to children who had never wheezed. Unadjusted and adjusted analyses for each maternal variable are presented. RR: relative risk; ALA: alpha-linolenic acid; DHA: docosahexaenoic acid; EPA: eicosapentaenoic acid; LA: linoleic acid; AA: arachidonic acid. RR derived from Poisson regression.
*Adjusted for maternal asthma and rhinitis, parity, child’s sex, and maternal educational attainment. †Adjusted for maternal asthma and rhinitis, paternal asthma, maternal smoking in pregnancy, child’s sex, and maternal educational attainment.
