The Clinical Significance of the Dense Fine Speckled Immunofluorescence Pattern on HEp-2 Cells for the Diagnosis of Systemic Autoimmune Diseases

<table>Identification of the dense fine speckled pattern is not always an easy task. The DFS pattern has to be differentiated from (a) speckled patterns generated by autoantibodies against RNP, Ro60 and SS-B (La), (b) from homogeneous patterns generated by anti-Scl-70 antibodies, and from (c) homogenous patterns generated by anti-dsDNA antibodies. DFS patterns generated by three different samples are shown in (d)–(f). Samples (d) and (e) are monospecific anti-DFS70 samples, and sample (f) also contains low titers of antibodies against extractable nuclear antigens (ENA).</table>

Journal of Immunology Research

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Figure 1

Figure 1: The Clinical Significance of the Dense Fine Speckled Immunofluorescence Pattern on HEp-2 Cells for the Diagnosis of Systemic Autoimmune Diseases 

Figure 1 | The Clinical Significance of the Dense Fine Speckled Immunofluorescence Pattern on HEp-2 Cells for the Diagnosis of Systemic Autoimmune Diseases 