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Clinical and Developmental Immunology
Volume 2012 (2012), Article ID 494356, 6 pages
The Clinical Significance of the Dense Fine Speckled Immunofluorescence Pattern on HEp-2 Cells for the Diagnosis of Systemic Autoimmune Diseases
1INOVA Diagnostics, Inc., 9900 Old Grove Road, San Diego, CA 32131-1638, USA
2Department of Medicine, Faculty of Medicine, University of Calgary, Calgary, AB, Canada T3H 1H7
Received 12 October 2012; Accepted 1 November 2012
Academic Editor: Dimitrios P. Bogdanos
Copyright © 2012 Michael Mahler and Marvin J. Fritzler. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Citations to this Article [35 citations]
The following is the list of published articles that have cited the current article.
- Chelsea Bentow, Andreas Swart, Jason Wu, Andrea Seaman, Mariangela Manfredi, Maria Infantino, Maurizio Benucci, Gabriella Lakos, and Michael Mahler, “Clinical performance evaluation of a novel rapid response chemiluminescent immunoassay for the detection of autoantibodies to extractable nuclear antigens,” Clinica Chimica Acta, 2013.
- Monica Bhagat, Shiv T. Sehra, Anupama Shahane, and Mildred Kwan, “Utility of Immunologic Testing in Suspected Rheumatologic Disease,” Current Allergy and Asthma Reports, vol. 14, no. 1, 2013.
- Renato Nisihara, Mariana Menine Kubis, Paula C. S. Rodrigues, Thelma Skare, Valmir Mocelin, and Shirley Utiyama, “Antinuclear Antibodies and Rheumatoid Factor Positivity in Healthy Elderly Adults: A Cross-Sectional Study in 336 Individuals,” Journal of the American Geriatrics Society, vol. 61, no. 11, pp. 2044–2046, 2013.
- Martina Frodlund, Orjan Dahlstrom, Alf Kastbom, Thomas Skogh, and Christopher Sjowall, “Associations between antinuclear antibody staining patterns and clinical features of systemic lupus erythematosus: analysis of a regional Swedish register,” Bmj Open, vol. 3, no. 10, 2013.
- Meghan K. Hickey, and Mandakolathur Murali, “Laboratory Testing in Neurorheumatology,” Seminars in Neurology, vol. 34, no. 4, pp. 378–385, 2014.
- Sylvie Coito, “Le point sur les anticorps anti-DFS70,” Revue Francophone des Laboratoires, vol. 2014, no. 464, pp. 7–11, 2014.
- Michael Mahler, Minoru Satoh, Marie Hudson, Murray Baron, Jason Y. F. Chan, Edward K. L. Chan, James Wick, and Marvin J. Fritzler, “Autoantibodies to the Rpp25 Component of the Th/To Complex are the Most Common Antibodies in Patients with Systemic Sclerosis without Antibodies Detectable by Widely Available Commercial Tests,” Journal of Rheumatology, vol. 41, no. 7, pp. 1334–1343, 2014.
- Michael Mahler, and Marvin J. Fritzler, “Antinuclear Antibodies in Children,” Journal of Rheumatology, vol. 41, no. 7, pp. 1260–1262, 2014.
- M. Mahler, and T. Dervieux, “Comments on recent advances and recommendations for the assessment of autoantibodies to cellular antigens referred as antinuclear antibodies,” Annals of the Rheumatic Diseases, vol. 73, no. 7, pp. e36–e36, 2014.
- Mandy Sowa, Kai Grossmann, Juliane Scholz, Nadja Roeber, Stefan Roediger, Peter Schierack, Karsten Conrad, Dirk Roggenbuck, and Rico Hiemann, “The CytoBead assay - a novel kind of multiparametric autoantibody analysis in the diagnostics of systemic autoimmune diseases,” Laboratoriumsmedizin-Journal Of Laboratory Medicine, vol. 38, no. 6, pp. 309–317, 2014.
- Karsten Conrad, Nadja Roeber, Sebastian Rudolph, and Michael Mahler, “DFS70 antibodies - biomarker for exclusion of ANA associated rheumatic diseases,” Laboratoriumsmedizin-Journal Of Laboratory Medicine, vol. 38, no. 6, pp. 299–307, 2014.
- Martina Fabris, Silvia Zago, Raffaello Tosolini, Paola Melli, Nicola Bizzaro, and Elio Tonutti, “Anti-DFS70 Antibodies: A Useful Biomarker in a Pediatric Case With Suspected Autoimmune Disease,” Pediatrics, vol. 134, no. 6, pp. E1706–E1708, 2014.
- Edda Rohwäder, Michael Locke, Johanna Fraune, and Kai Fechner, “Diagnostic profile on the IFA 40: HEp-20-10 – an immunofluorescence test for reliable antinuclear antibody screening,” Expert Review of Molecular Diagnostics, pp. 1–12, 2014.
- Chelsea Bentow, Gabriella Lakos, Rachel Rosenblum, Cassandra Bryant, Andrea Seaman, and Michael Mahler, “Clinical performance evaluation of a novel, automated chemiluminescent immunoassay, QUANTA Flash CTD Screen Plus,” Immunologic Research, 2014.
- Michael Mahler, Marvin J. Fritzler, and Minoru Satoh, “Autoantibodies to the mitochondrial RNA processing (MRP) complex also known as Th/To autoantigen,” Autoimmunity Reviews, 2014.
- Michael Mahler, Pier-Luigi Meroni, Xavier Bossuyt, and Marvin J. Fritzler, “Current Concepts and Future Directions for the Assessment of Autoantibodies to Cellular Antigens Referred to as Anti-Nuclear Antibodies,” Journal of Immunology Research, vol. 2014, pp. 1–18, 2014.
- Thomas Y. Avery, Mart van de Cruys, Jos Austen, Frans Stals, and Jan G. M. C. Damoiseaux, “Anti-Nuclear Antibodies in Daily Clinical Practice: Prevalence in Primary, Secondary, and Tertiary Care,” Journal of Immunology Research, vol. 2014, pp. 1–8, 2014.
- Edward K. L. Chan, Jan Damoiseaux, Orlando Gabriel Carballo, Karsten Conrad, Wilson de Melo Cruvinel, Paulo Luiz Carvalho Francescantonio, Marvin J. Fritzler, Ignacio Garcia-De La Torre, Manfred Herold, Tsuneyo Mimori, Minoru Satoh, Carlos A. von Mühlen, and Luis E. C. Andrade, “Report of the First International Consensus on Standardized Nomenclature of Antinuclear Antibody HEp-2 Cell Patterns 2014–2015,” Frontiers in Immunology, vol. 6, 2015.
- Anamika Basu, Leanne Woods-Burnham, Greisha Ortiz, Leslimar Rios-Colon, Johnny Figueroa, Roger Albesa, Luis E. Andrade, Michael Mahler, and Carlos A. Casiano, “Specificity of Antinuclear Autoantibodies Recognizing the Dense Fine Speckled Nuclear Pattern: Preferential Targeting of DFS70/LEDGFp75 Over its Interacting Partner MeCP2,” Clinical Immunology, 2015.
- Robert L. Ochs, Michael Mahler, Anamika Basu, Leslimar Rios-Colon, Tino W. Sanchez, Luis E. Andrade, Marvin J. Fritzler, and Carlos A. Casiano, “The significance of autoantibodies to DFS70/LEDGFp75 in health and disease: integrating basic science with clinical understanding,” Clinical and Experimental Medicine, 2015.
- Susana López Sañudo, Irene Fernández Alonso, and Marcos López Hoyos, “Importancia de la identificación del patrón moteado fino denso y de los anticuerpos anti-DFS70 en el diagnóstico de enfermedades autoinmunitarias del tejido conectivo,” Medicina Clínica, 2015.
- Anamika Basu, Tino W. Sanchez, and Carlos A. Casiano, “DFS70/LEDGFp75: An Enigmatic Autoantigen at the Interface between Autoimmunity, AIDS, and Cancer,” Frontiers in Immunology, vol. 6, 2015.
- Heinrike Schmeling, Michael Mahler, Deborah M. Levy, Katharine Moore, Anne M. Stevens, James Wick, Jacob D. McMillan, Gerd Horneff, Shervin Assassi, Julio Charles, Gloria Salazar, Maureen D. Mayes, Earl D. Silverman, Marissa Klien-Gitelman, Tzelan Lee, Hermine I. Brunner, Ann M. Reed, and Marvin J. Fritzler, “Autoantibodies to Dense Fine Speckles in Pediatric Diseases and Controls,” Journal Of Rheumatology, vol. 42, no. 12, pp. 2419–2426, 2015.
- A. C. Nilsson, A. Voss, and S. T. Lillevang, “DFS70 Autoantibodies are Rare in Healthy Danish Individuals but may Still Serve as a Diagnostic Aid,” Scandinavian Journal Of Immunology, vol. 82, no. 6, pp. 547–548, 2015.
- H Lee, Y Kim, K Han, and E-J Oh, “Application of anti-DFS70 antibody and specific autoantibody test algorithms to patients with the dense fine speckled pattern on HEp-2 cells,” Scandinavian Journal of Rheumatology, pp. 1–7, 2015.
- Marvin J. Fritzler, “Choosing wisely: Review and commentary on anti-nuclear antibody (ANA) testing,” Autoimmunity Reviews, 2015.
- Michael Mahler, Pier Luigi Meroni, Luis E. Andrade, Munther Khamashta, Nicola Bizzaro, Carlos A. Casiano, and Marvin J. Fritzler, “Towards a better understanding of the clinical association of anti-DFS70 autoantibodies,” Autoimmunity Reviews, 2015.
- Nicola Bizzaro, Elio Tonutti, Marilina Tampoia, Maria Infantino, Francesco Cucchiaro, Fiorenza Pesente, Gabriella Morozzi, Martina Fabris, and Danilo Villalta, “Specific chemoluminescence and immunoasdorption tests for anti-DFS70 antibodies avoid false positive results by indirect immunofluorescence,” Clinica Chimica Acta, 2015.
- Adeloisa Pajaro, Tony Nikoloutsopoulos, and Peter Roberts-Thomson, “Diagnostic utility of unidentified precipitin lines (UPLs) in immune precipitation assays,” Pathology, vol. 47, no. 1, pp. 62–67, 2015.
- Karsten Conrad, Nadja Röber, Sebastian Rudolph, and Michael Mahler, “DFS70 antibodies – biomarkers for the exclusion of ANA-associated autoimmune rheumatic diseases,” LaboratoriumsMedizin, vol. 38, no. 6, 2015.
- Christine M. Litwin, and Steven R. Binder, “ANA testing in the presence of acute and chronic infections,” Journal of Immunoassay and Immunochemistry, 2016.
- Andrew Broadfoot, Terri Sivertsen, and Karl Baumgart, “Dense fine speckled indirect immunofluorescence pattern in an Australian population,” Pathology, vol. 48, no. 3, pp. 247–250, 2016.
- Susana López Sañudo, Irene Fernández Alonso, and Marcos López Hoyos, “Importance of the dense fine speckled pattern and anti-DFS70 antibodies for the diagnosis of systemic autoimmune rheumatic diseases,” Medicina Clínica (English Edition), 2016.
- Jan Damoiseaux, Carlos A. von Mühlen, Ignacio Garcia-De La Torre, Orlando Gabriel Carballo, Wilson de Melo Cruvinel, Paulo Luiz Carvalho Francescantonio, Marvin J. Fritzler, Manfred Herold, Tsuneyo Mimori, Minoru Satoh, Luis E. C. Andrade, Edward K. L. Chan, and Karsten Conrad, “International consensus on ANA patterns (ICAP): the bumpy road towards a consensus on reporting ANA results,” Autoimmunity Highlights, vol. 7, no. 1, 2016.
- Esvet Mutlu, Mete Eyigor, Derya Mutlu, and Meral Gultekin, “Confirmation of anti-DFS70 antibodies is needed in routine clinical samples with DFS staining pattern,” Central European Journal Of Immunology, vol. 41, no. 1, pp. 6–11, 2016.