- About this Journal ·
- Abstracting and Indexing ·
- Aims and Scope ·
- Annual Issues ·
- Article Processing Charges ·
- Author Guidelines ·
- Bibliographic Information ·
- Citations to this Journal ·
- Contact Information ·
- Editorial Board ·
- Editorial Workflow ·
- Free eTOC Alerts ·
- Publication Ethics ·
- Recently Accepted Articles ·
- Reviewers Acknowledgment ·
- Submit a Manuscript ·
- Subscription Information ·
- Table of Contents
Clinical and Developmental Immunology
Volume 2012 (2012), Article ID 494356, 6 pages
The Clinical Significance of the Dense Fine Speckled Immunofluorescence Pattern on HEp-2 Cells for the Diagnosis of Systemic Autoimmune Diseases
1INOVA Diagnostics, Inc., 9900 Old Grove Road, San Diego, CA 32131-1638, USA
2Department of Medicine, Faculty of Medicine, University of Calgary, Calgary, AB, Canada T3H 1H7
Received 12 October 2012; Accepted 1 November 2012
Academic Editor: Dimitrios P. Bogdanos
Copyright © 2012 Michael Mahler and Marvin J. Fritzler. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- M. Mahler and M. J. Fritzler, “Epitope specificity and significance in systemic autoimmune diseases,” Annals of the New York Academy of Sciences, vol. 1183, pp. 267–287, 2010.
- G. J. Friou, S. C. Finch, and K. D. Detre, “Interaction of nuclei and globulin from lupus erythematosis serum demonstrated with fluorescent antibody,” The Journal of Immunology, vol. 80, no. 4, pp. 324–329, 1958.
- A. E. Moore, L. Sabachewsky, and H. W. Toolan, “Culture characteristics of four permanent lines of human cancer cells,” Cancer Research, vol. 15, no. 9, pp. 598–602, 1955.
- P. L. Meroni and P. H. Schur, “ANA screening: an old test with new recommendations,” Annals of the Rheumatic Diseases, vol. 69, no. 8, pp. 1420–1422, 2010.
- M. J. Fritzler and M. L. Fritzler, “The emergence of multiplexed technologies as diagnostic platforms in systemic autoimmune diseases,” Current Medicinal Chemistry, vol. 13, no. 21, pp. 2503–2512, 2006.
- S. Kivity, B. Gilburd, N. Agmon-Levin, et al., “A novel automated indirect immunofluorescence autoantibody evaluation,” Clinical Rheumatology, vol. 31, no. 3, pp. 503–509, 2012.
- K. Egerer, D. Roggenbuck, R. Hiemann et al., “Automated evaluation of autoantibodies on human epithelial-2 cells as an approach to standardize cell-based immunofluorescence tests,” Arthritis Research & Therapy, vol. 12, no. 2, article R40, 2010.
- M. Mahler, J. T. Ngo, J. Schulte-Pelkum, T. Luettich, and M. J. Fritzler, “Limited reliability of the indirect immunofluorescence technique for the detection of anti-Rib-P antibodies,” Arthritis Research & Therapy, vol. 10, no. 6, article R131, 2008.
- M. J. Fritzler, “The antinuclear antibody test: last or lasting gasp?” Arthritis & Rheumatism, vol. 63, no. 1, pp. 19–22, 2011.
- S. S. Copple, A. D. Sawitzke, A. M. Wilson, A. E. Tebo, and H. R. Hill, “Enzyme-linked immunosorbent assay screening then indirect immunofluorescence confirmation of antinuclear antibodies,” American Journal of Clinical Pathology, vol. 135, no. 5, pp. 678–684, 2011.
- K. Op De Beeck, P. Vermeersch, P. Verschueren et al., “Detection of antinuclear antibodies by indirect immunofluorescence and by solid phase assay,” Autoimmunity Reviews, vol. 10, no. 12, pp. 801–808, 2011.
- H. A. Mariz, E. I. Sato, S. H. Barbosa, S. H. Rodrigues, A. Dellavance, and L. E. C. Andrade, “Pattern on the antinuclear antibody-HEp-2 test is a critical parameter for discriminating antinuclear antibody-positive healthy individuals and patients with autoimmune rheumatic diseases,” Arthritis & Rheumatism, vol. 63, no. 1, pp. 191–200, 2011.
- A. Watanabe, M. Kodera, K. Sugiura et al., “Anti-DFS70 antibodies in 597 healthy hospital workers,” Arthritis & Rheumatism, vol. 50, no. 3, pp. 892–900, 2004.
- R. L. Ochs, Y. Muro, Y. Si, H. Ge, E. K. L. Chan, and E. M. Tan, “Autoantibodies to DFS 70 kd/transcription coactivator p75 in atopic dermatitis and other conditions,” The Journal of Allergy and Clinical Immunology, vol. 105, no. 6, pp. 1211–1220, 2000.
- V. Ganapathy and C. A. Casiano, “Autoimmunity to the nuclear autoantigen DFS70 (LEDGF): what exactly are the autoantibodies trying to tell us?” Arthritis & Rheumatism, vol. 50, no. 3, pp. 684–688, 2004.
- T. Daniels, J. Zhang, I. Gutierrez et al., “Antinuclear autoantibodies in prostate cancer: immunity to LEDGF/p75, a survival protein highly expressed in prostate tumors and cleaved during apoptosis,” Prostate, vol. 62, no. 1, pp. 14–26, 2005.
- M. Mahler, T. Parker, C. L. Peebles, et al., “Anti-DFS70/LEDGF antibodies are more prevalent in healthy individuals compared to patients with systemic autoimmune rheumatic diseases,” The Journal of Rheumatology, vol. 39, no. 11, pp. 2104–2110, 2012.
- A. Dellavance, V. S. T. Viana, E. P. Leon, E. S. D. O. Bonfa, L. E. C. Andrade, and P. G. Leser, “The clinical spectrum of antinuclear antibodies associated with the nuclear dense fine speckled immunofluorescence pattern,” The Journal of Rheumatology, vol. 32, no. 11, pp. 2144–2149, 2005.
- Y. Muro, K. Sugiura, Y. Morita, and Y. Tomita, “High concomitance of disease marker autoantibodies in anti-DFS70/LEDGF autoantibody-positive patients with autoimmune rheumatic disease,” Lupus, vol. 17, no. 3, pp. 171–176, 2008.
- Y. Muro, Y. Ogawa, K. Sugiura, and Y. Tomita, “HLA-associated production of anti-DFS70/LEDGF autoantibodies and systemic autoimmune disease,” Journal of Autoimmunity, vol. 26, no. 4, pp. 252–257, 2006.
- R. L. Ochs, T. W. Stein Jr., C. L. Peebles, R. F. Gittes, and E. M. Tan, “Autoantibodies in interstitial cystitis,” Journal of Urology, vol. 151, no. 3, pp. 587–592, 1994.
- N. Bizzaro, E. Tonutti, and D. Villalta , “Recognizing the dense fine speckled/lens epithelium-derived growth factor/p75 pattern on HEp-2 cells: not an easy task! Comment on the article by Mariz et al,” Arthritis & Rheumatism, vol. 63, no. 12, pp. 4036–4037.
- T. Shinohara, D. P. Singh, and L. T. Chylack Jr., “Review: age-related cataract: immunity and lens epithelium-derived growth factor (LEDGF),” Journal of Ocular Pharmacology and Therapeutics, vol. 16, no. 2, pp. 181–191, 2000.
- G. Maertens, P. Cherepanov, W. Pluymers et al., “LEDGF/p75 is essential for nuclear and chromosomal targeting of HIV-1 integrase in human cells,” The Journal of Biological Chemistry, vol. 278, no. 35, pp. 33528–33539, 2003.
- M. Mahler, J. G. Hanly, and M. J. Fritzler, “Importance of the dense fine speckled pattern on HEp-2 cells and anti-DFS70 antibodies for the diagnosis of systemic autoimmune diseases,” Autoimmunity Reviews, vol. 11, no. 9, pp. 642–645, 2012.
- N. Bizzaro, E. Tonutti, D. Visentini et al., “Antibodies to the lens and cornea in anti-DFS70-positive subjects,” Annals of the New York Academy of Sciences, vol. 1107, pp. 174–183, 2007.
- E. M. Tan, A. S. Cohen, and J. F. Fries, “The 1982 revised criteria for the classification of systemic lupus erythrematosus,” Arthritis & Rheumatism, vol. 25, no. 11, pp. 1271–1277, 1982.
- S. Narain, H. B. Richards, M. Satoh et al., “Diagnostic accuracy for lupus and other systemic autoimmune diseases in the community setting,” Archives of Internal Medicine, vol. 164, no. 22, pp. 2435–2441, 2004.
- M. R. Arbuckle, M. T. McClain, M. V. Rubertone et al., “Development of autoantibodies before the clinical onset of systemic lupus erythematosus,” The New England Journal of Medicine, vol. 349, no. 16, pp. 1526–1533, 2003.