Review Article

Review on the Relationship between Human Polyomaviruses-Associated Tumors and Host Immune System

Figure 2

Polyomaviruses LT Ag structure. The functional domains are defined as follows: DnaJ domain that binds cellular Hsc70, LXCXE motif that binds the proteins belonging to the pRb family, NLS domain, that is the nuclear organization signal, Helicase domain, and p53 binding domain, that binds the p53 cellular suppressor protein.
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