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Figure 1: Histopathology of intestinal changes in IL-10−/− mice. (a) Histology of proximal colon representative of wild-type (129Sv/Ev) mice (40x). No cellular infiltration between glands was found. (b) Proximal colon of 6-week-old IL-10−/− mice (40x). Mucosa and submucosa are similar to the ones in wild-type mice. (c) Proximal colon of 10-week-old IL-10−/− mice (40x). Multifocal infiltrations of leucocytes in the mucosa and submucosa. (d) Proximal colon of 16-week-old IL-10−/− mice (40x). Presence of transmural inflammation affecting the muscular layer can be observed. (e) Proximal jejunum representative of wild-type mice (100x). (f) Proximal jejunum of 6-week-old IL-10−/− mice (100x). (g) Proximal jejunum of 10-week-old IL-10−/− mice (100x). (h) Proximal jejunum of 16-week-old IL-10−/− mice showing enteritis and cellular infiltration in the lamina propria (asterisks) (100x). Tissues were stained with hematoxylin and eosin.