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Clinical and Developmental Immunology
Volume 2012 (2012), Article ID 568564, 8 pages
http://dx.doi.org/10.1155/2012/568564
Research Article

Systemic-Lupus-Erythematosus-Related Acute Pancreatitis: A Cohort from South China

1Department of Rheumatology, The 1st Affiliated Hospital, Sun Yat-Sen University, Guangzhou, Guangdong 510080, China
2Department of Internal Medicine/Rheumatology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA

Received 21 February 2012; Revised 26 April 2012; Accepted 29 April 2012

Academic Editor: Chaim Putterman

Copyright © 2012 Yanlong Yang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Acute pancreatitis (AP) is a rare but life-threatening complication of SLE. The current study evaluated the clinical characteristics and risk factors for the mortality of patients with SLE-related AP in a cohort of South China. Methods. Inpatient medical records of SLE-related AP were retrospectively reviewed. Results. 27 out of 4053 SLE patients were diagnosed as SLE-related AP, with an overall prevalence of 0.67%, annual incidence of 0.56‰ and mortality of 37.04%. SLE patients with AP presented with higher SLEDAI score ( 2 1 . 7 0 ± 1 0 . 3 2 versus 1 6 . 1 7 ± 7 . 5 1 , 𝑃 = 0 . 0 3 ), more organ systems involvement ( 5 . 7 0 ± 1 . 5 6 versus 3 . 9 6 ± 1 . 1 5 , 𝑃 = 0 . 0 0 1 ), and higher mortality (37.04% versus 0, 𝑃 = 0 . 0 0 1 ), compared to patients without AP. Severe AP (SAP) patients had a significant higher mortality rate compared to mild AP (MAP) (75% versus 21.05%, 𝑃 = 0 . 0 1 4 ). 16 SLE-related AP patients received intensive GC treatment, 75% of them exhibited favorable prognosis. Conclusion. SLE-related AP is rare but concomitant with high mortality in South Chinese people, especially in those SAP patients. Activity of SLE, multiple-organ systems involvement may attribute to the severity and mortality of AP. Appropriate glucocorticosteroid (GC) treatment leads to better prognosis in majority of SLE patients with AP.