CD4 T-Cell-Independent Antibody Response Reduces Enterovirus 71 Lethality in Mice by Decreasing Tissue Viral Loads
Figure 3
Anti-CD4 antibody treatment efficiently reduced CD4+ T cells in the spleen of wild-type mice. (a) The percentages of CD4+ T cells and CD19+ B cells in the spleens of wild-type mice treated with control antibody (− CD4 depletion) or anti-CD4 antibody (+ CD4 depletion) 7 days postinfection analyzed by flow cytometry are shown. CD4−/− mice serve as a control for the assay. (b) The average percentages of CD4+ T cells and CD19+ B cells in spleens of the indicated mouse groups are shown. The data shown are the mean values plus SE values (error bars) of 3 spleens.
