Genetics of SLE: Functional Relevance for Monocytes/Macrophages in Disease

Figure 2

TLR induced IFN production and signalling in SLE. A brief outline of the signalling pathways involved in the production of type I IFNs in SLE. Activation of the transcription factors downstream of endosomal TLRs and Fc Receptors leads to the production of type I IFNs. These IFNs are secreted and further detected by IFN receptors, further activating interferon stimulated genes.