Genetics of SLE: Functional Relevance for Monocytes/Macrophages in Disease

Table 1

Polymorphisms of genes associated with SLE outlined in this review.

Category	Gene	SNP	Ethnicity
Immune complex recognition	C1q [8, 17, 18]
	C1r [19]
	C1s [20]	Rs292001 [21]	Turkish [17], Mexican [18]
	C2 [22]
	C4 [8, 22–24]
Nucleic acid recognition		rs3853839 [25]	Chinese, Japanese [25]
		rs179019 [26]	Japanese [26]
	TLR7 [25]	rs179010 [26]
		rs179008 [27]	Brazilian [27]
		rs5743836 [27]	Brazilian [27]
	TLR9	rs352139 [28]	Japanese [28]
		rs352140 [29]	Chinese [29]
			Asian [30],
	IRF7	rs1131665 [30]	European American [30],
			African American [30]
		rs5030437 [12]
	TRAF6	rs4755453 [12]	African American [12]
		rs540386 [12]
		rs13192841 [31]	European [31]
		rs2230926 [31, 32]	European [31],
	TNFAIP3	rs6922466 [31]	Chinese Han [33]
		rs5029939 [34]	European [31]
		rs7708392 [35, 36]	Caucasian, Chinese [35, 36]
	TNIP1	rs10036748 [35, 36]	Japanese [26]
			Caucasian,; Chinese [35, 36]
Interferon signalling		rs7582694 [37]	Caucasian [37]
	STAT4	rs7601754 [38]	Caucasian [38]
		rs7574865 [38]	Caucasian [38],
			Northern Han Chinese [39]
		rs7582694 [40]	Caucasian [40]
	TYK2	rs280519 [41]	UK, Swedish [41]
		rs2304256 [13]	Scandinavian [13]
	IRF5	rs12720270 [42]	UK [42]
		rs10488631 [43]