Table 1: Clinical manifestations related to anti-Ro antibodies.

Clinical manifestationDiseaseRo52 specificityReference

Cutaneous manifestation
 PhotosensitivitySLE[17]
RA[18]
 Subacute cutaneous lesionSLE/SCLE[19, 20]
 PurpuraSLE[21, 22]
SS[23, 24]
RA[18]
 Cutaneous NLENLE[25]

Sicca symptomSS[26]
SSc[27]
RA[18, 28, 29]

ScleritisRA[28]

Interstitial lung diseaseSLE+[16, 30, 31]
SSc[32, 33]
PM/DM[34, 35]

Congenital heart disease
 Complete heart blockNLE[25, 3638]
 Prolonged QT intervalNLE[25]

Liver dysfunction
 Liver function test abnormalityNLE[25]
 High serum bilirubin levelPBC+[39]
 Advanced histological stagePBC+[39]
AIH-1+[40]

Musculoskeletal involvement
 MyositisPM/DM+[15, 41, 42]
 ArthritisSLE[43]

Hematological disorder
 LeukopeniaSS[23]
RA[18]
 LymphopeniaSS[23]
 NeutropeniaSLE[44]
NLE[25]
 AnemiaNLE[25]
RA[29]
 ThrombocytopeniaNLE[25]

Immunological disorder
 HypocomplementemiaRA[18]
 High serum IgG levelSS[23]
RA[28]
 High serum IgM levelPBC+[39]

SLE: systemic lupus erythematosus; RA: rheumatoid arthritis; SCLE: subacute cutaneous lupus erythematosus; SS: Sjögren’s syndrome; NLE: neonatal lupus erythematosus; SSc: systemic sclerosis; PM: polymyositis; DM: dermatomyositis; PBC: primary biliary cirrhosis; AIH-1: type 1 autoimmune hepatitis.