Clinical and Pathological Roles of Ro/SSA Autoantibody System

Table 1

Clinical manifestations related to anti-Ro antibodies.

Clinical manifestation	Disease	Ro52 specificity	Reference
Cutaneous manifestation
Photosensitivity	SLE		[17]
	RA		[18]
Subacute cutaneous lesion	SLE/SCLE		[19, 20]
Purpura	SLE		[21, 22]
	SS		[23, 24]
	RA		[18]
Cutaneous NLE	NLE		[25]
Sicca symptom	SS		[26]
	SSc		[27]
	RA		[18, 28, 29]
Scleritis	RA		[28]
Interstitial lung disease	SLE	+	[16, 30, 31]
	SSc		[32, 33]
	PM/DM		[34, 35]
Congenital heart disease
Complete heart block	NLE		[25, 36–38]
Prolonged QT interval	NLE		[25]
Liver dysfunction
Liver function test abnormality	NLE		[25]
High serum bilirubin level	PBC	+	[39]
Advanced histological stage	PBC	+	[39]
	AIH-1	+	[40]
Musculoskeletal involvement
Myositis	PM/DM	+	[15, 41, 42]
Arthritis	SLE		[43]
Hematological disorder
Leukopenia	SS		[23]
	RA		[18]
Lymphopenia	SS		[23]
Neutropenia	SLE		[44]
	NLE		[25]
Anemia	NLE		[25]
	RA		[29]
Thrombocytopenia	NLE		[25]
Immunological disorder
Hypocomplementemia	RA		[18]
High serum IgG level	SS		[23]
	RA		[28]
High serum IgM level	PBC	+	[39]

SLE: systemic lupus erythematosus; RA: rheumatoid arthritis; SCLE: subacute cutaneous lupus erythematosus; SS: Sjögren’s syndrome; NLE: neonatal lupus erythematosus; SSc: systemic sclerosis; PM: polymyositis; DM: dermatomyositis; PBC: primary biliary cirrhosis; AIH-1: type 1 autoimmune hepatitis.