Frequent Detection of Anti-Tubercular-Glycolipid-IgG and -IgA Antibodies in Healthcare Workers with Latent Tuberculosis Infection in the Philippines

Table 1

Demographic and clinical data of study participants.

Variables	HCWs (𝑛=31)	HIV-AC (𝑛=56)	𝑃
Demographic data
Gender: male; 𝑛 (%)	16 (51.6)	55 (96.5)	<0.0001*
Age year; median (range)	35 (19~62)	28 (19~48)	0.03*
Laboratory findings^†
Hemoglobin (g/dL)	13.2±2.6	13±1.49	0.36
RBC (million/μL)	4.96±1.6	4.43±.55	0.069
WBC (10^3/μL)	7.5±2.5	5.9±1.9	0.01*
Neutrophil (10^3/μL)	4.4±2.2	3.3±1.2	0.048*
Lymphocyte (10^3/μL)	2.4±0.6	2.2±0.9	0.82
Monocyte (/μL)	562±237	338±182	<0.001*
CD4+ T-cell count (/μL)	ND	443±286	NA
QFT assay positive; 𝑛 (%)	15 (48)	13 (23)	0.03*
TBGL-IgG positive; 𝑛 (%)	16 (51)	33 (59)	0.9
TBGL-IgA positive; 𝑛 (%)	6 (19)	16 (29)	0.87
IFN-γ-nc (IU/mL)	0.42±0.96	0.13±0.11	<0.001*
TBGL-IgG (U/mL)	3.12±3.36	3.94±6.63	0.14
TBGL-IgA (U/mL)	1.68±2.56	3.1±6.64	0.012*
Serum IgG (mg/dL)	1409±212	1391±224	0.49
Serum IgA (mg/dL)	246±92	319±138	0.058
OPN (ng/mL)	14.4±11	159±191	<0.00001*
Leptin (ng/mL)	18.6±13.9	7.2±5.4	<0.001*

Abbreviations: HCWs, healthcare workers; HIV-AC, newly diagnosed cases of asymptomatic human immune-deficiency virus infection; OPN, osteopontin; ND, not determined; NA, not applicable.
^† values were presented as mean ± SD unless indicated otherwise; IFN-γ-nc: levels of IFN-γ, measured in the nonstimulated QFT-plasma samples; 𝑃 values for statistical differences between HCW and HIV-AC; * significant differences (𝑃<0.05).