Frequent Detection of Anti-Tubercular-Glycolipid-IgG and -IgA Antibodies in Healthcare Workers with Latent Tuberculosis Infection in the Philippines

Table 2

Comparison between QFT-positive and QFT-negative HCWs and HIV-AC.

Variables	HCWs			HIV-AC
	QFT+ (𝑛=15)	QFT− (𝑛=16)	𝑃	QFT+ (𝑛=13)	QFT− (𝑛=43)	𝑃
Age; median (range)	45 (21~62)	23.5 (19~48)	0.002*	25 (19~45)	31 (21~35)	0.036*
Gender: male; 𝑛 (%)	7 (46.6)	9 (47.4)	0.43	12 (92.3)	42 (97.67)	0.43
Work duration->10 yrs; 𝑛 (%)	11(73.3)	6 (37.5)	0.098	NA	NA	NA
CD4+ count (/μL); median (range)	ND	ND	NA	611 (148~1466)	356 (13~1125)	0.012*
TBGL-IgG positive; 𝑛 (%)	11 (73)	5 (31)	0.02*	8 (61.5)	25 (58.13)	0.545
TBGL-IgA positive; 𝑛 (%)	5 (33)	1 (6)	0.072	3 (23)	13 (30)	0.415
TBGL-IgG+IgA positive; 𝑛 (%)	4 (27)	0 (0)	0.043*	2(15.4)	10 (23.3)	0.42
IFN-γ-nc (IU/mL)^†	0.3±0.4	0.2±0.13	0.9	0.21±0.17	0.1±0.07	0.0087*
Serum IgG (mg/dL)^†	1450±188	1368±235	0.2	1306±207	1414±249	0.5
Serum IgA (mg/dL)^†	268±81	225±101	0.32	330±130	312±138	0.68
OPN (ng/mL)^†	14.5±11.2	14.2±11.2	0.87	115.4±130	173.2±203	0.43
Leptin (ng/mL)^†	21.3±13.3	15.9±14.3	0.25	6.46±4.12	7.448±5.68	0.24

Abbreviations: HCWs, healthcare workers; HIV-AC, newly diagnosed cases of asymptomatic human immune-deficiency virus infection; OPN, osteopontin; ND, not determined; NA, not applicable.
^†mean ± SD; IFN-γ-nc: levels of IFN-γ, measured in the nonstimulated QFT-plasma samples; 𝑃 values for statistical differences between QFT-positive and QTF-negative groups; *significant differences (𝑃<0.05).