Frequent Detection of Anti-Tubercular-Glycolipid-IgG and -IgA Antibodies in Healthcare Workers with Latent Tuberculosis Infection in the Philippines

Table 3

Comparison between TBGL-IgG or TBGL-IgA-positive and -negative HIV-AC.

Variables	TBGL-IgG			TBGL-IgA
	Positive (𝑛=33)	Negative (𝑛=23)	𝑃	Positive (𝑛=16)	Negative (𝑛=40)	𝑃
Age; median (range)	28 (19~48)	30 (19~41)	0.18	31.5 (19~48)	28 (19~45)	0.038*
Gender: male; 𝑛 (%)	33 (100)	21 (91.3)	0.43	16 (100)	38 (95)	1
CD4 count (/μL); mean (range)	436 (13~1466)	450 (60~851)	0.45	346 (46~1125)	480 (13~1466)	0.06
QFT positive; 𝑛 (%)	8 (24.2)	5 (21.7)	0.545	3 (19)	10 (25)	0.45
TBGL-IgA positive; 𝑛 (%)	12 (36.4)	4 (17.4)	0.1	—	—	—
TBGL-IgG positive; 𝑛 (%)	—	—	—	12 (75)	21 (52.5)	0.14
IFN-γ-nc (IU/mL)^†	0.13±0.09	0.1±0.05	0.4	0.12±0.09	0.12±0.07	0.9
TBGL-IgA (U/mL)^†	4.36±8.4	1.28±1.21	0.041*	—	—
TBGL-IgG (U/mL)^†	—	—		7.5±11.6	2.5±1.5	0.042*
Serum IgG (mg/dL)^†	1439±277	1515±677	0.5	1615±404	1355±135	0.46
Serum IgA (mg/dL)^†	277±95	279±74	0.37	410±165	313±138	0.015*
OPN (ng/mL)^†	176.3±199.9	136±172.5	0.67	280±275	115±109.7	0.03*
Leptin (ng/mL)^†	7.33±6.16	7.18±4.12	0.68	7.33±6.16	7.18±4.12	0.07

Abbreviations: HIV-AC, newly diagnosed cases of asymptomatic human immune-deficiency virus infection; OPN, osteopontin.
^†mean ± SD; IFN-γ-nc: levels of IFN-γ, measured in the nonstimulated QFT-plasma samples; 𝑃 for statistical differences between QFT-positive and QTF-negative groups; *significant differences (𝑃<0.05).