Frequent Detection of Anti-Tubercular-Glycolipid-IgG and -IgA Antibodies in Healthcare Workers with Latent Tuberculosis Infection in the Philippines

Table 4

Comparison between HIV-AC with high^§ and low^‡ CD4+ T-cell count.

Variables	CD4+ high^§ (𝑛=32)	CD4+ low^‡ (𝑛=24)	𝑃 value^¶
Age; mean (range)	25.5 (19~45)	25 (22~48)	0.018*
Gender: male; 𝑛 (%)	31 (97)	23 (98)	1.0
CD4+ count (/μL); median (range)	618 (356~1466)	201 (13~349)	<0.001*
QFT-positive; 𝑛 (%)	10 (31)	3 (12.5)	0.12
TBGL-IgG positive; 𝑛 (%)	16 (50)	16 (67)	0.27
TBGL-IgA positive; 𝑛 (%)	5 (16)	11 (46)	0.018*
TBGL-IgG+ IgA positive; 𝑛 (%)	5 (16)	7 (29)	0.32
IFN-γ-nc (IU/mL)	0.14±0.12	0.13±0.09	0.9
TBGL-IgG (U/mL)^†	4.6±8.4	3±2.8	0.59
TBGL-IgA (U/mL)^†	1.55±2	5.16±9.6	0.048*
Serum IgG (mg/dL)^†	1352±185	1549±380	0.5
Serum IgA (mg/dL)^†	265±89	423±149	<0.001*
OPN (ng/mL)^†	119±126	214±246	0.19
Leptin (ng/mL)^†	7.7±6	6.6±4.9	0.5

Abbreviation: HIV-AC, newly diagnosed cases of asymptomatic human immune-deficiency virus infection; OPN: osteopontin.
^§High: CD4+ T cell count ≥350/μL; ^‡low: CD4+ T-cell count <350/μL; ^†mean±SD; IFN-γ-nc: levels of IFN-γ, measured in the non-stimulated QFT-plasma samples; 𝑃 values for statistical differences between QFT-positive and QTF-negative groups; *significant differences (𝑃<0.05).