Cytotoxic Activity of Dendritic Cells as a Possible Mechanism of Negative Regulation of T Lymphocytes in Pulmonary Tuberculosis

Table 1

The numbers of PD-1⁺CD4⁺ and PD-1⁺CD8⁺ T cells among the healthy donor MNC.

	N	PD-1^+CD4^+ T-cells (%)	PD-1^+CD8^+ T-cells (%)
Freshly isolated MNC	7	3.2 ± 0.7	2.5 ± 0.5
MNC stimulated with healthy donor DCs	6	5.1 ± 0.9*	8.8 ± 1.2*
MNC stimulated with TB patient DCs	23	8.1 ± 0.9*	10.2 ± 0.9*

The numbers (%) of PD-1⁺CD4⁺ and PD-1⁺CD8⁺ T-cells in peripheral blood MNC of healthy donors and in MNC cultivated for 3 days with allogeneic DCs were presented. The percentage of PD-1⁺CD4⁺ and PD-1⁺CD8⁺ T-cells in the cultures of MNC stimulated with TB patient DCs or healthy donor DCs was statistically higher than the number of PD-1⁺CD4⁺ and PD-1⁺CD8⁺ T-cells in freshly isolated MNC separated from peripheral blood (*𝑃_𝑢 < 0.05).