Review Article
Indolent B-Cell Lymphomas Associated with HCV Infection: Clinical and Virological Features and Role of Antiviral Therapy
Table 2
Antiviral treatment in patients with indolent B-cell lymphoma associated with HCV infection.
| | Year | N° pts | Diagnosis | Genotypes | Cryoglobulinemia | Antiviral treatment | Virologic response | NHL response |
| | Bauduer [63] | 1996 | 1 | MZL of MALT (oral cavity) | NA | — | α-IFN | 1 | 1 PR | | Caramaschi et al. [64] | 1999 | 1 | MZL of MALT (salivary glands) | NA | — | α-IFN | NA | 1 CR | | Moccia et al. [65] | 1999 | 3 | SMZL | NA | — | α-IFN | NA | 2 CR | | Patriarca et al. [66] | 2001 | 1 | LPL | 2a/2c | — | α-IFN | 1 | 1 CR | | Hermine et al. [5] | 2002 | 9 | SLVL | NA | 6 | α-IFN | 7 | 7 CR | | Casato et al. [67] | 2002 | 1 | Leukemic MZL | NA | 1 | α-IFN | Decreased HCV-RNA | 1 CR | | Pitini et al. [68] | 2004 | 2 | SMZL | NA | — | α-IFN | 2 | 2 CR | | Tursi et al. [69] | 2004 | 16 | MZL of MALT (stomach) | NA | — | α-IFN-2b + RBV | 11/16 | 16 CR | | Kelaidi et al. [70] | 2004 | 8 | SMZL ()
Disseminated
MZL ()
Leukemic MZL ()
MZL of MALT () (1 duodenus; 1 ileus) | 3a (), 5a ()
—
1b
4c/4d | 8 | α-IFN-2b + RBV | 5 SVR, 2 PR | 5 CR | | Vallisa et al. [71] | 2005 | 13 | SMZL ()
NMZL ()
MZL of MALT ()
FL ()
LPL () | 1b (), 2b ()
2a/2c (), 1b ()
1b ()
2a
2a/2c (), 1n (),
na () | 5 | Peg-IFN + RBV | 7 SVR, 1 PR | 7 CR, 2 PR | | Svoboda et al. [72] | 2005 | 1 | MZL of MALT (salivary gland, liver) | 2b | — | Peg-IFN + RBV | 1 | CR | | Saadoun et al. [17] | 2005 | 18 | SLVL | 1 ()
2 ()
3 ()
4 () | 18 | α-IFN (+ RBV in 10) | 14 CR, 4 PR | 14 CR, 4 PR | | Paulli et al. [21] | 2009 | 2 | Subcutaneous MZL of MALT | 2a/2c
2b | 2 | Peg-IFN + RBV | 2 CR | 1 CR, 1 PR | | Oda et al. [73] | 2010 | 1 | B-NHL (liver) | 2a | — | Peg-IFN + RBV | SVR | CR | | Mauro et al. [74] | 2012 | 1 | LPL | 1b | 1 | Peg-IFN + RBV (2nd line) | SVR | CR | | Mazzaro et al. [75] | 2009 | 18 | 1 SLVL
1 FL
16 LPL | 1b ()
2a/2c () | 13 | α-IFN + RBV ()
Peg-IFN + RBV () | 9 SVR | 9 CR, 4 PR |
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SMZL: splenic marginal zone lymphoma; NMZL: nodal marginal zone lymphoma; SLVL: splenic lymphoma with villous lymphocytes; MZL: marginal zone lymphoma; FL: follicular lymphoma; LPL: lymphoplasmacytic lymphoma; MCL: mantle cell lymphoma; SLL: small lymphocytic lymphoma; NHL: non-Hodgkin’s lymphoma; NOS: not otherwise specified; IFN: interferon; RBV: ribavirin; CR: complete response; PR: partial response; SVR: sustained virologic response.
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