- About this Journal ·
- Abstracting and Indexing ·
- Aims and Scope ·
- Annual Issues ·
- Article Processing Charges ·
- Articles in Press ·
- Author Guidelines ·
- Bibliographic Information ·
- Citations to this Journal ·
- Contact Information ·
- Editorial Board ·
- Editorial Workflow ·
- Free eTOC Alerts ·
- Publication Ethics ·
- Reviewers Acknowledgment ·
- Submit a Manuscript ·
- Subscription Information ·
- Table of Contents
Clinical and Developmental Immunology
Volume 2012 (2012), Article ID 640835, 8 pages
Ileal Inflammation May Trigger the Development of GP2-Specific Pancreatic Autoantibodies in Patients with Crohn’s Disease
1Division of Transplantation Immunology and Mucosal Biology, King’s College London School of Medicine at King’s College Hospital, London SE5 9RJ, UK
2Department of Gastroenterology and Clinical Nutrition, University College Hospital, 250 Euston Road, London NW1 2PG, UK
3Cellular Immunotherapy and Molecular Immunodiagnostics, Center for Research and Technology, Thessaly, 41222 Larissa, Greece
4Faculty of Natural Science, Lausitz University of Applied Sciences, 01968 Senftenberg, Germany
5GA Generic Assays GmbH, L.-Erhard-Ring 3, Dahlewitz, 15827 Berlin, Germany
6Department of Medicine, University of Thessaly Medical School, Viopolis, Larissa 41110, Greece
7Institute of Immunology, Technical University Dresden, Fetscherstrasse 74, 01307 Dresden, Germany
Received 22 June 2012; Accepted 7 September 2012
Academic Editor: Xavier Bossuyt
Copyright © 2012 Polychronis Pavlidis et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- W. Stöcker, M. Otte, S. Ulrich et al., “Autoimmunity to pancreatic juice in Crohn's disease. Results of an autoantibody screening in patients with chronic inflammatory bowel disease,” Scandinavian Journal of Gastroenterology, Supplement, vol. 139, pp. 41–52, 1987.
- W. Stöcker, M. Otte, S. Ulrich, D. Normann, K. Stöcker, and G. Jantschek, “Autoantibodies against the exocrine pancreas and against intestinal goblet cells in the diagnosis of Crohn’s disease and ulcerative colitis,” Deutsche Medizinische Wochenschrift, vol. 109, pp. 1963–1969, 1984.
- S. Desplat-Jégo, C. Johanet, A. Escande et al., “Update in Anti-Saccharomyces cerevisiae antibodies, anti-nuclear associated anti-neutrophil antibodies and antibodies to exocrine pancreas detected by indirect immunofluorescence as biomarkers in chronic inflammatory bowel diseases: results of a multicenter study,” World Journal of Gastroenterology, vol. 13, no. 16, pp. 2312–2318, 2007.
- F. Seibold, P. Weber, H. Jenss, and K. H. Wiedmann, “Antibodies to a trypsin sensitive pancreatic antigen in chronic inflammatory bowel disease: specific markers for a subgroup of patients with Crohn's disease,” Gut, vol. 32, no. 10, pp. 1192–1197, 1991.
- F. H. Klebl, F. Bataille, C. Huy, F. Hofstädter, J. Schölmerich, and G. Rogler, “Association of antibodies to exocrine pancreas with subtypes of Crohn's disease,” European Journal of Gastroenterology and Hepatology, vol. 17, no. 1, pp. 73–77, 2005.
- B. Desir, D. K. Amre, S. E. Lu et al., “Utility of serum antibodies in determining clinical course in pediatric Crohn's disease,” Clinical Gastroenterology and Hepatology, vol. 2, no. 2, pp. 139–146, 2004.
- U. Müller-Ladner, V. Gross, T. Andus et al., “Distinct patterns of immunoglobulin classes and IgG subclasses of autoantibodies in patients with inflammatory bowel disease,” European Journal of Gastroenterology and Hepatology, vol. 8, no. 6, pp. 579–584, 1996.
- D. Roggenbuck, G. Hausdorf, L. Martinez-Gamboa et al., “Identification of GP2, the major zymogen granule membrane glycoprotein, as the autoantigen of pancreatic antibodies in Crohn's disease,” Gut, vol. 58, no. 12, pp. 1620–1628, 2009.
- T. C. Hoops and M. J. Rindler, “Isolation of the cDNA encoding glycoprotein-2 (GP-2), the major zymogen granule membrane protein: homology to uromodulin/Tamm-Horsfall protein,” Journal of Biological Chemistry, vol. 266, no. 7, pp. 4257–4263, 1991.
- S. I. Fukuoka, S. D. Freedman, and G. A. Scheele, “A single gene encodes membrane-bound and free forms of GP-2, the major glycoprotein in pancreatic secretory (zymogen) granule membranes,” Proceedings of the National Academy of Sciences of the United States of America, vol. 88, no. 7, pp. 2898–2902, 1991.
- K. Hase, K. Kawano, T. Nochi et al., “Uptake through glycoprotein 2 of FimH+ bacteria by M cells initiates mucosal immune response,” Nature, vol. 462, no. 7270, pp. 226–230, 2009.
- D. P. Bogdanos, E. I. Rigopoulou, D. S. Smyk, D. Roggenbuck, D. Reinhold, A. Forbes, et al., “Diagnostic value, clinical utility and pathogenic significance of reactivity to the molecular targets of Crohn's disease specific-pancreatic autoantibodies,” Autoimmunity Reviews, vol. 11, pp. 143–148, 2011.
- H. Ohno and K. Hase, “Glycoprotein 2 (GP2) grabbing the fimH+ bacteria into m cells for mucosal immunity,” Gut Microbes, vol. 1, no. 6, pp. 407–410, 2010.
- J. P. Kraehenbuhl and M. R. Neutra, “Epithelial M cells: differentiation and function,” Annual Review of Cell and Developmental Biology, vol. 16, pp. 301–332, 2000.
- J. E. Lennard-Jones, “Classification of inflammatory bowel disease,” Scandinavian Journal of Gastroenterology, Supplement, vol. 170, pp. 2–6, 1989.
- M. S. Silverberg, J. Satsangi, T. Ahmad, I. D. Arnott, C. N. Bernstein, S. R. Brant, et al., “Toward an integrated clinical, molecular and serological classification of inflammatory bowel disease: report of a Working Party of the 2005 Montreal World Congress of Gastroenterology,” Canadian Journal of Gastroenterology, vol. 19, pp. 5–36, 2005.
- D. Roggenbuck, D. Reinhold, T. Wex et al., “Autoantibodies to GP2, the major zymogen granule membrane glycoprotein, are new markers in Crohn's disease,” Clinica Chimica Acta, vol. 412, no. 9-10, pp. 718–724, 2011.
- D. Roggenbuck, D. Reinhold, T. Wex et al., “Authors' response: antibodies to GP2, the major zymogen granule membrane glycoprotein, are specific for Crohn's disease and may reflect treatment response,” Gut, vol. 61, pp. 164–165, 2012.
- B. Bonaci-Nikolic, M. Spuran, S. Andrejevic, and M. Nikolic, “Autoantibodies to GP2, the major zymogen granule membrane glycoprotein, in patients with gluten-sensitive enteropathy: a possible serological trap,” Clinica Chimica Acta, vol. 413, pp. 822–823, 2012.
- P. L. Lakatos, I. Aitorjay, T. Szamosi et al., “Pancreatic autoantibodies are associated with reactivity to microbial antibodies, penetrating disease behavior, perianal disease, and extraintestinal manifestations, but not with NOD2/CARD15 or TLR4 genotype in a Hungarian IBD cohort,” Inflammatory Bowel Diseases, vol. 15, no. 3, pp. 365–374, 2009.
- K. O. De Beéck, S. Vermeire, P. Rutgeerts, and X. Bossuyt, “Antibodies to GP2, the major zymogen granule membrane glycoprotein, in inflammatory bowel diseases,” Gut, vol. 61, pp. 162–164, 2012.
- P. Pavlidis, A. Forbes, and D. P. Bogdanos, “Antibodies to glycoprotein 2 (GP2) in patients with inflammatory bowel diseases from UK,” Clinica Chimica Acta, vol. 412, no. 11-12, pp. 1163–1164, 2011.
- M. Kovacs, P. L. Lakatos, M. Papp, S. Jacobsen, E. Nemes, M. Polgar, et al., “Pancreatic autoantibodies and autoantibodies against goblet cells in pediatric patients with inflammatory bowel disease (IBD),” Journal of Pediatric Gastroenterology and Nutrition, vol. 55, no. 4, pp. 429–435, 2012.
- M. A. Hölzl, J. Hofer, J. J. Kovarik et al., “The zymogen granule protein 2 (GP2) binds to scavenger receptor expressed on endothelial cells I (SREC-I),” Cellular Immunology, vol. 267, no. 2, pp. 88–93, 2011.
- R. L. Owen, “Uptake and transport of intestinal macromolecules and microorganisms by M cells in Peyer's patches: a personal and historical perspective,” Seminars in Immunology, vol. 11, no. 3, pp. 157–163, 1999.
- M. R. Neutra, A. Frey, and J. P. Kraehenbuhl, “Epithelial M cells: gateways for mucosal infection and immunization,” Cell, vol. 86, no. 3, pp. 345–348, 1996.
- K. Hase, S. Ohshima, K. Kawano et al., “Distinct gene expression profiles characterize cellular phenotypes of follicle-associated epithelium and M cells,” DNA Research, vol. 12, no. 2, pp. 127–137, 2005.
- E. Gullberg and J. D. Söderholm, “Peyer's patches and M cells as potential sites of the inflammatory onset in Crohn's disease,” Annals of the New York Academy of Sciences, vol. 1072, pp. 218–232, 2006.
- L. Herszenyi and Z. Tulassay, “The role of autoantibodies in inflammatory bowel diseases,” Digestive Diseases, vol. 30, pp. 201–207, 2012.
- C. Huang and S. Kugathasan, “markers that differentiate early from late IBD,” Digestive Diseases, vol. 30, pp. 380–382, 2012.
- A. Kaul, S. Hutfless, L. Liu, T. M. Bayless, M. R. Marahn, and X. Li, “Serum anti-glycan antibody biomarkers for inflammatory bowel diseases diagnosis and progression: a systematic review and metanalysis,” Inflammatory Bowel Diseases, vol. 18, no. 10, pp. 1872–1884, 2012.
- L. Werner, D. Paclik, C. Fritz, D. Reinhold, D. Roggenbuck, and A. Sturm, “Identification of pancreatic glycoprotein 2 as an endogenous immunomodulator of innate and adaptive immune responses,” The Journal of Immunology, vol. 189, no. 6, pp. 2774–2783, 2012.