Research Article
Automated Indirect Immunofluorescence Evaluation of Antinuclear Autoantibodies on HEp-2 Cells
Table 1
Comparison of software-based and visual positive/negative classification.
| | | Visual evaluation | | | Collective A () | Collective B () | Total () | | | Positive | Negative | Positive | Negative | Positive | Negative |
| | EUROPattern | | | | | | | | Positive | 193 | 1 | 79 | 1 | 272 | 2 | | Negative | 0 | 6 | 0 | 71 | 0 | 77 | | Concordance | 99.5% | 99.3% | 99.4% | | -value | 0.921 | 0.987 | 0.984 | | Sensitivity | 100% | 100% | 100% | | Specificity | 85.7% | 98.6% | 97.5% | | PPV | 99.5% | 98.8% | 99.3% | | NPV | 100% | 100% | 100% |
|
|
: kappa-value indicating interrater agreement, PPV: positive predictive value, NPV: negative predictive value.
|
