In Vitro Release of Interferon-Gamma from Peripheral Blood Lymphocytes in Cutaneous Adverse Drug Reactions

Table 6

Sensitivity and specificity of the IFN-gamma release test, and positive and negative likelihood ratio according to patient’s age groups, sex, and type of rash.

Age group/sex	Sensitivity (%); 95% CI (range)	Specificity (%); 95% CI (range)	Likelihood ratio for a positive test; 95% CI (range)	Likelihood ratio for a negative test; 95% CI (range)
≤44 years	85.25 (74.28–92.04)	88.57 (83.01–92.48)	7.46 (4.87–11.41)	0.17 (0.09–0.13)
45–64 years	75.86 (63.47–85.04)	91.71 (87.12–94.76)	9.15 (5.67–14.75)	0.26 (0.17–0.42)
≥65 years	88.89 (78.8–94.51)	95.79 (92.94–97.53)	21.3 (12.32–36.23)	0.12 (0.06–0.23)
Women	87.30 (80.37–92.03)	93.38 (90.6–95.38)	13.19 (9.16–18.98)	0.14 (0.09–0.22)
Men	75.44 (62.9–84.77)	91.51 (87.47–94.32)	8.88 (5.8–13.6)	0.27 (0.17–0.42)
Vasculitis	100 (75.75–100)	96.97 (84.68–99.46)	33.0 (4.79–37.7)	0.00
All other skin reactions	82.46 (76.06–87.43)	92.45 (90.16–94.24)	10.9 (8.27–14.42)	0.19 (0.14–0.26)