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Clinical and Developmental Immunology
Volume 2012 (2012), Article ID 690571, 10 pages
http://dx.doi.org/10.1155/2012/690571
Review Article

T Cells in Gastric Cancer: Friends or Foes

1Patologia Medica, Dipartimento de Biomedicina, Azienda Ospedaliera Universitaria Careggi, Largo Brambilla 3, 50134 Firenze, Italy
2Department of Internal Medicine, University of Florence, Florence 50134, Italy
3Department of Medical and Surgical Critical Care, University of Florence, Florence 50134, Italy

Received 27 January 2012; Revised 15 March 2012; Accepted 27 March 2012

Academic Editor: Nejat Egilmez

Copyright © 2012 Amedeo Amedei et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Gastric cancer is the second cause of cancer-related deaths worldwide. Helicobacter pylori is the major risk factor for gastric cancer. As for any type of cancer, T cells are crucial for recognition and elimination of gastric tumor cells. Unfortunately T cells, instead of protecting from the onset of cancer, can contribute to oncogenesis. Herein we review the different types, “friend or foe”, of T-cell response in gastric cancer.