Epithelial-to-Mesenchymal Transition in Pancreatic Ductal Adenocarcinoma and Pancreatic Tumor Cell Lines: The Role of Neutrophils and Neutrophil-Derived Elastase

<table>PMN or PMN-elastase induce dyshesion of tumor cells and loss of E-cadherin: pancreatic cancer cells (T3 M4; upper panel) and liver cancer cells (HuH7, lower panel) were seeded as monolayers (a and e), and then incubated with PMN (b and f), or PMN-elastase (c and g) for three hours (magnification ×400; d, h are zooms thereof). Dyshesion of cells was observed, and cells assumed a spindle shaped form (in d and h marked by an arrow). </table>

Journal of Immunology Research

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Figure 2: Epithelial-to-Mesenchymal Transition in Pancreatic Ductal Adenocarcinoma and Pancreatic Tumor Cell Lines: The Role of Neutrophils and Neutrophil-Derived Elastase 

Figure 2 | Epithelial-to-Mesenchymal Transition in Pancreatic Ductal Adenocarcinoma and Pancreatic Tumor Cell Lines: The Role of Neutrophils and Neutrophil-Derived Elastase 