Oral Tolerance Induced by Transfer of Food Antigens via Breast Milk of Allergic Mothers Prevents Offspring from Developing Allergic Symptoms in a Mouse Food Allergy Model

Figure 6

Effects of the maternal exposure to food antigens during lactation and the maternal allergic status on OVA-specific IgG1 and IgA levels in breast milk. We found OVA-specific IgG1 only in the breast milk from OVA-sensitized mothers, which implies that mother mice secrete IgG1 into their breast milk. We found OVA-specific IgA only in the breast milk from OVA-sensitized and OVA-exposed mothers. Data are shown as the means and individual data points. N.D.: not detectable. *𝑃<0.05, **𝑃<0.01, n = 5–9.