Clinical Study

Intrauterine Growth Restriction: Cytokine Profiles of Trophoblast Antigen-Stimulated Maternal Lymphocytes

Table 2

Means of ratios of proinflammatory to anti-inflammatory cytokines. All possible combinations of pro- and anti-inflammatory cytokines were compared, but only the ones which are significantly different are presented in this table. I > N indicates that the ratio is higher in IUGR than in normal pregnancy, WO > N indicates that the ratio in IUGR without placental insufficiency subgroup is higher than in normal pregnancy group, and so on.

Cytokine ratioNormal pregnancy control
(N)
Total IUGR
(I)
IUGR with placental insufficiency
(W)
IUGR without placental insufficiency
(WO)
Significant differences

IL-6/IL-13326518134714222189I  > N
WO > N

IL-8/IL-106794W > WO

IL-8/IL-1319711695261285I > N
WO > N

IL-12/IL-414172610W > WO

IL-12/IL-100.040.080.130.04W > N
W > WO

IL-12/IL-131.4648I > N
W > N

IFNγ/IL-100.140.230.440.09N > WO

TNFα/IL-131121091101I > N

IL-23/IL-4357248210273N > I
C > W
N > WO

IL-23/IL-10231.41.71.2N > I
N > WO

IL-23/IL-135823099238N > WO