Role of Immune Escape Mechanisms in Hodgkin's Lymphoma Development and Progression: A Whole New World with Therapeutic Implications

Figure 4

Representation of the two immune patterns observed in HL significantly associated with their clinicopathological features. The immunosurveillance pattern with a high proportion of infiltrating T lymphocytes, NK cells, DCs, activated CTL, but low proportion of resting CTL and TAM is associated with a favorable outcome. The immune escape pattern with a high proportion of infiltrating resting CTL and TAM, but low proportion of T lymphocytes, NK cells, DCs, and activated CTL is associated with an unfavorable outcome. MC, mixed cellularity; NS, nodular sclerosis; CR, complete response.