Interferon Regulatory Factor 5 in the Pathogenesis of Systemic Lupus Erythematosus
Figure 3
Diagram showing relationships between SLE-associated autoantibodies, IRF5 genotype and IFN-α involved in the pathogenesis of SLE [64]. This suggests a “feed-forward” model in which specific auto-antibodies interact with particular IRF5 risk variants which also predispose to the same antibody formation.
