Toll-Like Receptor Transcriptome in the HPV-Positive Cervical Cancer Microenvironment
Figure 1
TLR gene expression in normal, dysplastic and carcinoma ex vivo cervical tissue. Scatterplot indicating relative TLR gene expression levels (logged) in normal, dysplastic and carcinoma samples in the epithelium (a) and stroma (b) compartment. Horizontal bars show the average expression levels per group for each gene. Asterisks show significant expression differences from normal samples according to the Student’s -test for pairwise comparisons. Reported average relative expression values for each gene in both tissue compartments (c), values calculated according to * 1,000. Fold change values for TLRs in dysplastic and carcinoma samples (d). Significant fold change values according to the Student’s -test for pairwise comparison of two types are indicated with a thick border, and genes with significant upregulation trends according to the Jonckheere-Terpstra test are shaded gray.
