Sustained High Level of Serum VEGF at Convalescent Stage Contributes to the Renal Recovery after HTNV Infection in Patients with Hemorrhagic Fever with Renal Syndrome

Table 2

Characteristics of the HFRS patients at different stages of the disease.

HFRS stage	Sample number	Mean level of blood urea (mmol/L)^a	Mean level of serum creatinine (𝜇mol/L)^a	Mean level of leukocyte (*1000/𝜇L)^a	Mean level of platelet (*1000/𝜇L)^a	Mean level of serum albumin (g/L)^a	Proteinuria^b	Mean level of serum VEGF (pg/mL)^c
Febrile	32	14.5 (8.7–20.3)	182.5 (133.3–231.8)	17.1 (9.0–25.2)	53.9 (40.4–67.4)	30.7 (28.8–32.7)	(−)–(+)	454.9 (351.9–557.9)
Hypotensive	15	16.3 (11.8–20.8)	250.2 (170.5–329.9)	28.9 (18.8–39.1)	25.4 (15.6–35.1)	25.6 (22.8–28.3)	(±)–(+++)	473.7 (312.4–634.9)
Oliguric	34	18.6 (15.5–21.8)	391.3 (312.2–470.5)	14.5 (11.1–17.9)	95.1 (62.5–127.6)	30.1 (28.3–31.9)	(+)–(+++)	596.0 (460.5–731.4)
Diuretic	54	10.1 (8.5–11.8)	243.9 (195.0–292.9)	7.7 (7.0–8.5)	199.0 (175.4–222.7)	37.0 (35.7–38.4)	(±)–(++)	752.1 (620.2–884.1)*
Convalescence	25	8.9 (5.1–12.7)	150.2 (102.1–198.2)	6.3 (5.5–7.1)	227.9 (161.4–294.5)	39.9 (37.4–42.5)	(−)–(+)	543.0 (405.0–681.0)
8 months after	37	—	—	—	—	—	—	201.2 (161.7–240.7)**

^aThe clinical parameters were statistically analyzed with the records on the same day that we had obtained and detected the VEGF from the serum samples. The data were presented as mean (95% confidence interval).
^bThe severity range of proteinuria of the patients at different stages of HFRS.
^cVEGF: vascular endothelial growth factor. The mean level of serum VEGF was statistically analyzed at each stage without considering the different severity of the disease.
*The serum VEGF level at diuretic stage of the patients was higher than that at other stages, P < 0.05.
**The serum VEGF level of the patients 8 months after discharge was significant lower than that at any stage of the hospitalization, P < 0.01.