Increased Frequency of Circulating Follicular Helper T Cells in Patients with Rheumatoid Arthritis
Figure 3
Increased Bcl-6 mRNA, IL-21 mRNA expression, and plasma IL-21 concentration in RA patients. (a) Detection of Bcl-6 mRNA expression in RA patients and healthy controls. Bcl-6 mRNA was estimated by real-time RT-PCR. Data correspond to the of 7 RA patients and 7 healthy controls (**). (b) Detection of IL-21 mRNA expression in RA patients and healthy controls. IL-21 mRNA was estimated by real-time RT-PCR. Data correspond to the of 7 RA patients and 7 healthy controls (**). (c) Plasma IL-21 concentration in RA patients () and healthy controls () (*). (d) Relationship between plasma IL-21 concentration and the frequency of circulating Tfh cells in RA patients (, ) ().
