- About this Journal ·
- Abstracting and Indexing ·
- Advance Access ·
- Aims and Scope ·
- Annual Issues ·
- Article Processing Charges ·
- Articles in Press ·
- Author Guidelines ·
- Bibliographic Information ·
- Citations to this Journal ·
- Contact Information ·
- Editorial Board ·
- Editorial Workflow ·
- Free eTOC Alerts ·
- Publication Ethics ·
- Reviewers Acknowledgment ·
- Submit a Manuscript ·
- Subscription Information ·
- Table of Contents
Clinical and Developmental Immunology
Volume 2012 (2012), Article ID 827480, 7 pages
Increased Frequency of Circulating Follicular Helper T Cells in Patients with Rheumatoid Arthritis
1Department of Laboratory Medicine, The Affiliated People’s Hospital, and School of Medical Science and Laboratory Medicine, Jiangsu University, Zhenjiang 212013, China
2Department of Nuclear Medicine, Affiliated Hospital of Jiangsu University, Zhenjiang, China
3Department of Pathology and Center of Infection and Immunology, The University of Hong Kong, Hong Kong
4Zhenjiang Key Laboratory of Medical Immunology, Affiliated Hospital of Jiangsu University, Zhenjiang, China
Received 16 October 2011; Revised 24 January 2012; Accepted 31 January 2012
Academic Editor: E. Shevach
Copyright © 2012 Jie Ma et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- G. S. Firestein, “Evolving concepts of rheumatoid arthritis,” Nature, vol. 423, no. 6937, pp. 356–361, 2003.
- N. Fazilleau, L. J. McHeyzer-Williams, and M. G. McHeyzer-Williams, “Local development of effector and memory T helper cells,” Current Opinion in Immunology, vol. 19, no. 3, pp. 259–267, 2007.
- J. Jacob, G. Kelsoe, K. Rajewsky, and U. Weiss, “Intraclonal generation of antibody mutants in germinal centres,” Nature, vol. 354, no. 6352, pp. 389–392, 1991.
- K. L. Calame, “Plasma cells: finding new light at the end of B cell development,” Nature Immunology, vol. 2, no. 12, pp. 1103–1108, 2001.
- R. I. Nurieva, Y. Chung, D. Hwang et al., “Generation of T follicular helper cells is mediated by interleukin-21 but independent of t helper 1, 2, or 17 cell lineages,” Immunity, vol. 29, no. 1, pp. 138–149, 2008.
- L. Zhou, I. I. Ivanov, R. Spolski et al., “IL-6 programs T(H)-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways,” Nature Immunology, vol. 8, no. 9, pp. 967–974, 2007.
- N. Fazilleau, L. Mark, L. J. McHeyzer-Williams, and M. G. McHeyzer-Williams, “Follicular helper T cells: lineage and location,” Immunity, vol. 30, no. 3, pp. 324–335, 2009.
- T. Chtanova, S. G. Tangye, R. Newton et al., “T follicular helper cells express a distinctive transcriptional profile, reflecting their role as non-Th1/Th2 effector cells that provide help for B cells,” Journal of Immunology, vol. 173, no. 1, pp. 68–78, 2004.
- D. Breitfeld, L. Ohl, E. Kremmer et al., “Follicular B helper T cells express CXC chemokine receptor 5, localize to B cell follicles, and support immunoglobulin production,” The Journal of Experimental Medicine, vol. 192, no. 11, pp. 1545–1551, 2000.
- D. Yu, S. Rao, L. M. Tsai et al., “The transcriptional repressor Bcl-6 directs T follicular helper cell lineage commitment,” Immunity, vol. 31, no. 3, pp. 457–468, 2009.
- N. Simpson, P. A. Gatenby, A. Wilson et al., “Expansion of circulating T cells resembling follicular helper T cells is a fixed phenotype that identifies a subset of severe systemic lupus erythematosus,” Arthritis and Rheumatism, vol. 62, no. 1, pp. 234–244, 2010.
- F. C. Arnett, S. M. Edworthy, D. A. Bloch et al., “The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis,” Arthritis and Rheumatism, vol. 31, no. 3, pp. 315–324, 1988.
- S. Wang, H. Xu, Y. Wang et al., “Regulatory T cells induced by rAAV carrying the forkhead box P3 gene prevent autoimmune thyroiditis in mice,” International Journal of Molecular Medicine, vol. 18, no. 6, pp. 1193–1199, 2006.
- C. King, S. G. Tangye, and C. R. Mackay, “T follicular helper (TFH) cells in normal and dysregulated immune responses,” Annual Review of Immunology, vol. 26, pp. 741–766, 2008.
- C. G. Vinuesa, S. G. Tangye, B. Moser, and C. R. Mackay, “Follicular B helper T cells in antibody responses and autoimmunity,” Nature Reviews Immunology, vol. 5, no. 11, pp. 853–865, 2005.
- C. Zhu, J. Ma, Y. Liu, et al., “Increased frequency of follicular helper T cells in patients with autoimmune thyroid disease,” The Journal of Clinical Endocrinology & Metabolism, vol. 97, no. 3, pp. 943–950, 2012.
- M. A. Linterman, R. J. Rigby, R. K. Wong et al., “Follicular helper T cells are required for systemic autoimmunity,” The Journal of Experimental Medicine, vol. 206, no. 3, pp. 561–576, 2009.
- A.-U. Rasheed, H.-P. Rahn, F. Sallusto, M. Lipp, and G. Müller, “Follicular B helper T cell activity is confined to CXCR5hiICOShi CD4 T cells and is independent of CD57 expression,” European Journal of Immunology, vol. 36, no. 7, pp. 1892–1903, 2006.
- E. C. Franklin, H. R. Holman, H. J. Muller-Eberhard, and H. G. Kunkel, “An unusual protein component of high molecular weight in the serum of certain patients with rheumatoid arthritis,” The Journal of Experimental Medicine, vol. 105, no. 5, pp. 425–438, 1957.
- W. J. Van Venrooij and A. J.W. Zendman, “Anti-CCP2 antibodies: an overview and perspective of the diagnostic abilities of this serological marker for early rheumatoid arthritis,” Clinical Reviews in Allergy and Immunology, vol. 34, no. 1, pp. 36–39, 2008.
- S. Agrawal, R. Misra, and A. Aggarwal, “Autoantibodies in rheumatoid arthritis: association with severity of disease in established RA,” Clinical Rheumatology, vol. 26, no. 2, pp. 201–204, 2007.
- T. Cantaert, L. De Rycke, T. Bongartz et al., “Citrullinated proteins in rheumatoid arthritis: crucial... but not sufficient!,” Arthritis and Rheumatism, vol. 54, no. 11, pp. 3381–3389, 2006.
- V. L. Bryant, C. S. Ma, D. T. Avery et al., “Cytokine-mediated regulation of human B cell differentiation into Ig-secreting cells: predominant role of IL-21 produced by CXCR5+ T follicular helper cells,” Journal of Immunology, vol. 179, no. 12, pp. 8180–8190, 2007.
- T. K. Rasmussen, T. Andersen, M. Hvid et al., “Increased interleukin 21 (IL-21) and IL-23 are associated with increased disease activity and with radiographic status in patients with early rheumatoid arthritis,” Journal of Rheumatology, vol. 37, no. 10, pp. 2014–2020, 2010.
- C. H. Kim, H. W. Lim, J. R. Kim, L. Rott, P. Hillsamer, and E. C. Butcher, “Unique gene expression program of human germinal center T helper cells,” Blood, vol. 104, no. 7, pp. 1952–1960, 2004.
- R. I. Nurieva, Y. Chung, G. J. Martinez et al., “Bcl6 mediates the development of T follicular helper cells,” Science, vol. 325, no. 5943, pp. 1001–1005, 2009.