Emergence of Exhausted B Cells in Asymptomatic HIV-1-Infected Patients Naïve for HAART is Related to Reduced Immune Surveillance
Figure 2
Association between exhausted tissue-like memory B cells and HIV plasma viremia. Correlation between CD10−CD27− B cell percentages and HIV-1 plasma viremia (RNA copies/mL) in asymptomatic HIV-1-infected patients (a). Comparative analysis of CD10−CD27− B cell percentages in asymptomatic patients with HIV-1 plasma viremia ≤ to 10000 RNA copies/mL and asymptomatic patients with HIV-1 plasma viremia > to 10000 RNA copies/mL (b). Association of 2 different data groups were analyzed by Spearman’s rank test; and rho values are indicated. Each symbol represents one individual, and regression line is shown. Differences between groups were evaluated using the two-tailed Mann-Whitney test, and were considered significant at . Into the box plots, horizontal lines represent median values for each group, boxes show the 25th and 75th percentiles, and bars show SD.
