Emergence of Exhausted B Cells in Asymptomatic HIV-1-Infected Patients Naïve for HAART is Related to Reduced Immune Surveillance

Table 3

Effects of HAART on B cells frequency, IL-7 serum levels, and TTV viral load.

	Healthy	Asymptomatic HIV-1 infected	HAART treated	P (HAART treated versus healthy)	P (HAART treated versus asymptomatic HIV-1 infected)
CD19^+ B cell count (cell/μL)	143.0	129.5	232.5	<0.01	<0.005
CD21^−CD27^− B cell frequency (%)	2.1	10.4	2.7	NS	<0.0001
CD21^−CD27^+ B cell frequency (%)	2.4	9.6	1.7	NS	<0.0001
CD21^+CD27^+ B cell frequency (%)	29.4	23.5	22.4	<0.05	NS
CD21^+CD27^− B cell frequency (%)	64.4	54.2	73.0	NS	<0.0005
IL-7 serum level (pg/mL)	1.7	12.9	2.0	NS	<0.01
TTV plasma viremia (log DNA copies/mL)	4.6	5.7	4.1	NS	<0.001

NS: not significant.
Results are expressed as median.