Mitochondrial Mutations are Associated with Atherosclerotic Lesions in the Human Aorta

Table 1

Comparison of the level of heteroplasmy for ten mitochondrial mutations in homogenates of unaffected intimal samples and atherosclerotic lesions.

Mutation	The level of heteroplasmy (%)*		P **
	Unaffected tissue	Lipofibrous plaque
652insG	3 (4)	1 (3)	NS
A1555G	13 (8)	20 (11)	0.001
C3256T	8 (4)	18 (7)	<0.001
T3336C	2 (2)	6 (5)	0.006
C5178A	12 (11)	15 (17)	NS
G12315A	15 (12)	20 (14)	0.069
G13513A	26 (7)	19 (11)	0.019
G14459A	5 (3)	7 (4)	0.054
G14846A	8 (6)	10 (9)	NS
G15059A	11 (11)	28 (14)	<0.001

*The level of heteroplasmy is expressed as a mean, SD is shown in
parentheses.
**The significance of differences was estimated by Wilcoxon signed-
rank test; NS: nonsignificant differences.