Beneficial Effect of Bupleurum Polysaccharides on Autoimmune-Prone MRL-lpr Mice

Figure 4

Effect of BPs on urinary protein and serum creatinine levels of MRL-lpr and BALB/c mice. MRL-lpr mice were grouped randomly and treated with BPs 15, 30, and 60 mg·kg⁻¹·day⁻¹, prednisone 5 mg·kg⁻¹·day⁻¹, or model from week 12 to week 24; mice were sacrificed and the supernatant of urine was diluted 1 : 3 in normal saline; the serum creatinine was measured with Jaffe method; data were expressed as means ± S.D. (𝑛=6–8); *𝑃<0.05, **𝑃<0.01, ***𝑃<0.001 compared with vehicle-treated model group, tested by ANOVA and Fisher’s PLSD.

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