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Clinical and Developmental Immunology
Volume 2012 (2012), Article ID 854795, 4 pages
http://dx.doi.org/10.1155/2012/854795
Research Article

Association of Autoantibodies to BP180 with Disease Activity in Greek Patients with Bullous Pemphigoid

12nd Department of Dermatology and Venereology, Papageorgiou General Hospital, Aristotle University School of Medicine, Nea Eflkarpia, Ring Road Thessalonikis, 56403 Thessaloniki, Greece
2Immunology Laboratory, Papageorgiou General Hospital, Nea Eflkarpia, Ring Road Thessalonikis, 56403 Thessaloniki, Greece

Received 7 September 2012; Revised 24 October 2012; Accepted 25 October 2012

Academic Editor: Dimitrios P. Bogdanos

Copyright © 2012 Aikaterini Patsatsi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

39 bullous pemphigoid (BP) patients were studied to assess the clinical significance of anti-BP180 and anti-BP230 circulating autoantibodies of BP and correlate their titers with the clinical scores of the BP Disease Area Index (BPDAI) and the Autoimmune Bullous Skin Disorder Intensity Score (ABSIS) as well as with the intensity of pruritus measured by the BPDAI pruritus component. All parameters were evaluated by the time of diagnosis (baseline), month 3, and month 6. Titers of anti-BP180 autoantibodies were strongly correlated with BPDAI ( , ) and ABSIS ( , ) values, as well as with BPDAI component for the intensity of pruritus ( , ) at baseline. At month 3, titers of anti-BP180 autoantibodies were strongly correlated with BPDAI ( , ) and ABSIS ( , ) values, as well as with the BPDAI component for the intensity of pruritus ( , ). At month 6, titers of anti-BP180 autoantibodies were strongly correlated with BPDAI ( , ) and ABSIS ( , ) values, as well as with the BPDAI component for the intensity of pruritus ( , ). There was no statistically significant correlation between titers of anti-BP230 autoantibodies and the BPDAI, ABSIS, and BPDAI component for the intensity of pruritus at the same time points.