PD-L1-Expressing Dendritic Cells Contribute to Viral Resistance during Acute HSV-1 Infection
Figure 4
Cytokine expression following HSV-1 infection and treatment with anti-PD-L1 or anti-PD-L2 antibody. C57BL/6 mice were infected with 1,000 PFU HSV-1/cornea. At days 2, 4, and 6 p.i. mice were administered neutralizing antibody to PD-L1, PD-L2, or control IgG. At day 7 p.i. mice were exsanguinated and the TG was processed for suspension array or ELISA. (a) IFN-γ levels. (b) CXCL1 levels. (c) CCL2 levels. (d) CCL5 levels. (e) CXCL10 levels. Cytokine levels are a summary of two to three experiments (–9). Each bar represents the mean ± SEM expressed in pg/mg of tissue. * comparing the indicated group to the isotypic control antibody-treated group.
