Impact of Previous ART and of ART Initiation on Outcome of HIV-Associated Tuberculosis
Table 2
Multivariable odds ratios* of unsuccessful outcome of tuberculosis treatment and death according to baseline characteristics for 246 HIV-infected patients with tuberculosis.
Variable
Unsatisfactory outcome of TB treatment
Death
OR (95% CI)
value
OR (95% CI)
value
Sex
Male
1.00
1.00
Female
0.38 (0.16–0.90)
0.029
0.35 (0.10–1.27)
0.112
Place of origin
Born in Italy
1.00
1.00
Foreign born
3.66 (1.48–9.06)
0.005
1.98 (0.52–7.45)
0.314
Age at TB diagnosis (years)
<40
1.00
1.00
≥40
1.04 (0.52–2.11)
0.909
2.34 (0.94–5.84)
0.068
Education (years)
0–8
1.00
1.00
9–18
1.00 (0.44–2.27)
0.996
0.81 (0.27–2.37)
0.698
Unknown
0.83 (0.35–1.96)
0.671
0.69 (0.20–2.35)
0.550
History of imprisonment
Yes
1.00
1.00
No/unknown
1.93 (0.65–5.74)
0.238
2.17 (0.53–8.90)
0.282
Mode of HIV infection
Injecting drug use
1.00
1.00
Other
0.42 (0.19–0.93)
0.033
0.25 (0.08–0.74)
0.012
Housing
Private
1.00
1.00
Community/homeless
2.21 (0.93–5.30)
0.074
0.44 (0.09–2.30)
0.333
CD4 lymphocyte count (increase: 50 cells)
0.96 (0.88–1.04)
0.326
0.83 (0.71–0.97)
0.020
AIDS
Yes
1.00
1.00
No
0.90 (0.45–1.82)
0.778
0.44 (0.16–1.19)
0.106
Site of diseases
Pulmonary
1.00
1.00
Extra pulmonary
0.66 (0.29–1.50)
0.320
1.15 (0.42–3.18)
0.782
History of TB treatment
New cases
1.00
1.00
Previously treated cases
0.96 (0.39–2.36)
0.930
0.71 (0.22–2.32)
0.572
Drug susceptibility test
Susceptible TB
1.00
1.00
DR TB
1.03 (0.33–3.21)
0.962
0.44 (0.07–2.69)
0.376
MDR TB
0.83 (0.03–20.52)
0.911
37.10 (1.98–693.79)
0.016
Not available
1.41 (0.71–2.78)
0.322
1.24 (0.50–3.07)
0.649
Awareness of HIV seropositivity and HIV treatment history
Not aware
1.00
1.00
Aware and cART naive
5.11 (2.04–12.80)
0.001
2.95 (0.77–11.33)
0.115
Not cART naive
3.31 (1.29–8.46)
0.013
4.04 (1.09–14.96)
0.037
Concomitant diseases at TB diagnosis
Yes
1.00
1.00
No
1.38 (0.59–3.26)
0.461
0.59 (0.23–1.55)
0.286
*From polytomous logistic regression model with successful outcome as reference category.
