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Clinical and Developmental Immunology
Volume 2012 (2012), Article ID 949821, 8 pages
http://dx.doi.org/10.1155/2012/949821
Research Article

Downregulation of Hlx Closely Related to the Decreased Expressions of T-bet and Runx3 in Patients with Gastric Cancer May Be Associated with a Pathological Event Leading to the Imbalance of Th1/Th2

1Department of Immunology, Institute of Laboratory Medicine, Jiangsu University, Zhenjiang 212013, China
2Department of Laboratory Medicine, The Affiliated People’s Hospital, Jiangsu University, Zhenjiang 212001, China

Received 19 August 2012; Revised 19 October 2012; Accepted 22 October 2012

Academic Editor: T. Nakayama

Copyright © 2012 Yan Xu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

T-bet plays an important role in immunoregulation; it induces the differentiation of Th1 together with the homeobox transcription factor gene Hlx. Recent studies show that T-bet and Th1-associated factors are critical in regulating tumor development. However, the contributions of Hlx in the occurrence and development of cancer remain unknown. In this study, the Hlx, T-bet, Runx3, and IFN-γ were measured in PBMC from patients with gastric cancer and the correlation between Hlx and T-bet or IFN-γ was assessed. The expression levels of Hlx, T-bet, and IFN-γwere significantly decreased, and there was a positive correlation between Hlx and T-bet or IFN-γ. In addition, the Runx3 expression was also downregulated with the lower T-bet mRNA level. These results suggested that the decreased Hlx expression was closely associated with T-bet and Runx3 downregulations and may contribute to the development of gastric cancer.