Association of Intrarenal B-Cell Infiltrates with Clinical Outcome in Lupus Nephritis: A Study of 192 Cases

Figure 1

Microanatomical organization of inflammatory infiltrates. Serial staining for CD3, CD20, and CD21 allowed classification into four different grades. Grade 0 aggregates consist of T cell infiltrates alone (no B cells) (not shown). Grade 1 aggregates consist of scattered T- and B-cell infiltrates (original magnification: ×400). Grade 2 aggregates show a cluster-like structure. No T- and B-cell zones are evident. Grade 3 aggregates show clearly distinguishable T- and B-cell areas (original magnification: ×200).