Table 4: Genes with different regulation in polyoma BK nephropathy.

GeneControl groupBKVN groupP value*

C3 0.06 (0.02–0.6)0.375 (0.03–5.27)0.022
CCL2 0.06 (0.01–0.12)0.22 (0.03–0.85)0.005
CCL3 0.12 (0–0.65)0.71 (0.16–5.89)0.02
CCL5 3.26 (0.41–45.4)66.9 (7.9–235)0.003
CCR2 0 (0–6.38)20.7 (0–158)0.001
CCR7 0 (0–659)35.3 (0–789)0.017
CD19 0 (0–104)109 (0–2440)0.013
CD28 1.36 (0–75.1)59.3 (0.74–448)0.012
CD4 3.32 (0.22–15.1)27 (6.63–209)0.004
CD68 0.61 (0.05–1.38)1.68 (0.97–4.79)0.001
CD86 0.67 (0.01–16.9)10 (0.88–32.3)0.012
CSF1 1.42 (0.02–4.89)5.17 (0.57–71.3)0.049
CXCL10 0.05 (0–2.9)1.8 (0.06–3.76)0.015
CXCR3 0 (0–34.3)61.2 (0–671)0.013
EDN1 0.45 (0.14–1.32)1.18 (0.39–8.74)0.025
FASL 0 (0–67.2)145.72 (25.96–409.25)0.003
GNLY 0.36 (0.12–2.1)4.9 (1.45–52.2)0.001
HLADRA 0.39 (0.15–3.27)1.55 (0.503–7.6)0.021
HLA-DRB1 0 (0–0.39)0.85 (0–85.6)0.036
ICAM1 0.03 (0–0.8)0.235 (0.06–13.1)0.03
IFNG 2.65 (0–139)82.1 (0–519)0.023
IL12B 0 (0–3.83)3.49 (0–37.6)0.03
IL1B 0.17 (0–0.95)1.38 (0.3–3.67)0.002
IL2RA 0.14 (0–3.44)3.32 (0.47–19)0.009
IL6 0.05 (0.01–3.49)0.72 (0.07–9.49)0.048
IL8 0.55 (0–6.75)14.7 (0.11–53.4)0.004
LTA 0 (0–93.9)68.8 (0–903)0.036
PRF1 8.7 (0–43.3)117 (1.4–4100)0.007
PTPRC 1.52 (0.55–24.6)47.6 (4.7–303)0.001
TBX21 0 (0–15.2)7.14 (0–383)0.036
TGFB 0.73 (0.23–6.75)3.42 (0.73–13)0.025
TNF 0.61 (0.04–3.18)8.2 (0.95–30.7)0.002
TNFRSF18 0 (0–1.77)1.7 (0–19.5)0.01

Data are shown as median (minimum–maximum) of relative quantity (RQ) of gene expression calculated with regard to the reference gene (GAPDH) and calibrator.
* P values calculated by Mann-Whitney U test followed by the Bonferroni adjustment.