Evaluation of Clinical Interest of Anti-Aquaporin-4 Autoantibody Followup in Neuromyelitis Optica
Figure 2
Detailed evolution of anti-AQP4 serum reactivity and comparison with disease course in patients 1 to 6. Serum anti-AQP4 Ab concentration (black triangle) was measured with a cell-based assay using AQP4 expressing human 293 T cells and flow cytometry as described in Section 2. EDSS score indicates the level of impairment (grey circle); vertical dashed arrows represent relapses (all relapses were treated with corticosteroids); horizontal arrows indicate a treatment (AZA: azathioprine; CX: monthly administration of IV corticoids; INF B: interferon beta; MMF: mycophenolate mofetil; PE: plasma exchange; MTX: mitoxantrone).
