Potential Use of Bisphosphonates in Invasive Extramammary Paget’s Disease: An Immunohistochemical Investigation

Figure 4

Schematic representation of antitumor effect of BPs. BPs might suppress the progression of EMPD as follows: induction of tumor apoptosis, inhibition of the function of immunosuppressive macrophages, inhibition of tumor adhesion, inhibition of tumor invasion, and inhibition of MMP activity.