Table 2: Analytical performance of ICARE algorithm for ANA screening.

Positive versus negativeWeakly positive versus negative

Sensitivity94.5%85.7%
Specificity98.1%98.1%
PPV98.5%95.5%
NPV93.5%93.5%
Kappa0.9230.861

PPV: positive predictive value, NPV: negative predictive value.
Kappa: Cohen’s kappa coefficient.