Original Approach for Automated Quantification of Antinuclear Autoantibodies by Indirect Immunofluorescence

Table 2

Analytical performance of ICARE algorithm for ANA screening.

	Positive versus negative	Weakly positive versus negative
Sensitivity	94.5%	85.7%
Specificity	98.1%	98.1%
PPV	98.5%	95.5%
NPV	93.5%	93.5%
Kappa	0.923	0.861

PPV: positive predictive value, NPV: negative predictive value.
Kappa: Cohen’s kappa coefficient.