Journal of Immunology Research / 2013 / Article / Tab 1 / Clinical Study
Autologous CIK Cell Immunotherapy in Patients with Renal Cell Carcinoma after Radical Nephrectomy Table 1 (a) Demographic, clinical, and pathological manifestations of patients with CIK cells treatment. (b) Demographic, clinical, and pathological manifestations of patients without CIK cells treatment. (c) Comparison of the Motzer Criteria Factors between two groups.
(a) Case Age/sex Nidus Pathologic stage before Nx (TNM) Location of metastases Disease state before CIK cell treatment CIK cycles Disease state after CIK cell treatment Disease state by the end of followup PFS (month) OS (month) UPN 1 69/M Left T1N0M0 — CR 4 CR CR 31 31 UPN 2 43/M Right T1N0M0 — CR 4 CR CR 42 42 UPN 3 60/M Left T1N0M0 — CR 4 CR CR 37 37 UPN 4 53/M Left T2N0M1 Lung PD 8 PR SD 17 28 UPN 5 61/M Left T1N0M0 — CR 4 CR CR 40 40 UPN 6 57/M Right T2N0M1 Lung PD 8 PR SD 38 41 UPN 7 79/F Left T2N1M0 Retroperitoneal lymph nodes PD 8 SD SD 12 26 UPN 8 50/M Right T1N0M0 — CR 5 CR CR 40 40 UPN 9 63/M Right T2N0M0 — CR 4 CR CR 32 32 UPN 10 47/M Left T1N0M1 Brain (left temporal lobe) PD 12 SD SD 33 33
RCC: renal cell carcinoma; CIK: cytokine-induced killer; TNM: tumornodemetastasis. (b) Case Age/sex Nidus Pathologic stage before Nx (TNM) Location of metastases at the beginning of followup Disease state at the beginning of followup Treatment protocols Disease state after treatment Disease state by the end of followup PFS (month) OS (month) UPN 11* 64/M Right T1N0M0 — CR Partial left nephrectomy CR CR 22 36 UPN 12 45/F Left T1N0M0 — CR — CR 32 32 UPN 13 41/M Left T1N0M1 Lung PR Chemotherapy + targeted therapy SD PD 7 30 UPN 14 77/M Right T1N1M0 Retroperitoneal lymph nodes SD IFN-
+ IL-2 PR SD 11 38 UPN 15 27/M Left T1N0M0 — CR — CR 40 40 UPN 16 66/M Left T1N0M1 Cervical vertebra PD Chemotherapy + radiotherapy SD PD 12 35 UPN 17 60/M Right T2N0M0 — CR Chemotherapy PR SD 19 36 UPN 18 45/M Left T1N0M0 — CR — CR 29 29 UPN 19 65/F Left T2N0M1 Right adrenal gland PR Chemotherapy PR SD 16 32 UPN 20 46/M Right T1N0M0 — CR — CR 28 28
UPN 11: the patient got left renal metastasis during the course of followup and got CR again after partial left nephrectomy till the end of followup.(c) Factors Group 1 Group 2
Karnofsky performance status (KPS) (
, %) 80–100 6 7 — 60–80 4 3 — Corrected calcium (mmol/L)
0.926 LDH level (U/L)
0.893 Hemoglobin level (g/L)
0.634 Time from diagnosis to systemic radical nephrectomy (
1 year) (
, %) 10 (100%) 10 (100%) —
Group 1: CIK cells treatment group; group 2: control group.
; there are no statistical significant differences between two groups.