Polyomavirus JC in the Context of Immunosuppression: A Series of Adaptive, DNA Replication-Driven Recombination Events in the Development of Progressive Multifocal Leukoencephalopathy
Figure 2
Potential stability of palindromes folded as hairpins in the NCCR region of JCV archetype and Mad-1 strains. Folding [72] was modeled at 55°C using JCV circular, single strands in 0.14 M NaCl and 3 mM MgCl2. NCCR regions are highlighted in pink. The arrow denotes the palindrome typed in blue and boxed in Figure 1(b). Note that sequence rearrangements in Mad-1 remove internal hairpins present in the archetype.
