Journal of Immunology Research

Review Article

Autoantibodies and the Immune Hypothesis in Psychotic Brain Diseases: Challenges and Perspectives

Table 1

Psychiatric symptoms associated with antibodies to cell surface autoantigens.
Psychiatric symptomReported antigens [30–35]
PsychosisNMDAR, D2R, LGI1, CASPR2, AMPAR, GABABR, mGluR5
ManiaNMDAR
AgitationNMDAR, D2R, LGI1, CASPR2, AMPAR, GABABR, mGluR5
Emotional labilityNMDAR, D2R, mGluR5
AnxietyNMDAR, D2R, LGI1, CASPR2, mGluR5
AggressionNMDAR, D2R
Compulsive behaviourNMDAR, D2R
Memory impairment, amnesiaNMDAR, LGI1, CASPR2, AMPAR, GABABR, mGluR5
Personality changeNMDAR, D2R, LGI1, CASPR2
ConfusionNMDAR, D2R, LGI1, CASPR2, mGluR5
D2R: dopamine-2 receptor; NMDAR: N-methyl-D-aspartate receptor; LGI1: leucine-rich glioma inactivated 1; CASPR2: contactin-associated protein-like 2; AMPAR: α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor; GABABR: γ-aminobutyric acid type B receptor; mGluR5: metabotropic glutamate receptor 5.