Mesenchymal Stem Cells in Immune-Mediated Bone Marrow Failure Syndromes

Table 3

Summary of BM MSC characteristics in MDS, acquired AA, and CIN patients.

	MDS	Acquired AA	CIN
Immunophenotype	Normal	Normal	Normal
Cell morphology	Aberrant	Aberrant	N.D.
Cell growth	Defective	Defective	Defective
Senescence	Increased	N.D.	N.D.
Multipotency	Defective (?)	Defective	Normal
Genomic profile	Frequent genetic aberrations, unrelated to HSC abnormalities	Aberrant gene expression profile	N.D.
Methylation profile	Altered	N.D.	N.D.
Immune properties	Impaired mainly in low-risk MDS	Impaired (?)	Normal
Haemopoietic support capacity	Impaired (?)	N.D.	N.D.

A question mark (?) indicates that existing data are still inconclusive or contradictory, and N.D. indicates the lack of associated data.