Table 3: Summary of BM MSC characteristics in MDS, acquired AA, and CIN patients.

MDSAcquired AACIN

ImmunophenotypeNormalNormalNormal
Cell morphologyAberrantAberrantN.D.
Cell growthDefectiveDefectiveDefective
SenescenceIncreasedN.D.N.D.
MultipotencyDefective ( )DefectiveNormal
Genomic profileFrequent genetic aberrations, unrelated to HSC abnormalitiesAberrant gene expression profileN.D.
Methylation profileAlteredN.D.N.D.
Immune propertiesImpaired mainly in low-risk MDSImpaired ( )Normal
Haemopoietic support capacityImpaired ( )N.D.N.D.

A question mark ( ) indicates that existing data are still inconclusive or contradictory, and N.D. indicates the lack of associated data.