The Leech Nervous System: A Valuable Model to Study the Microglia Involvement in Regenerative Processes
Figure 4
Transformation of resident microglia (m) into activated cells allowing their migration to the injury site. (a) and (c) Immunohistochemical staining using anti-gliarin antibody in ramified microglial cells from connectives (a), ramified microglial cells from ganglia (a′), and rounded microglial cells during their recruitment in connectives (c). (b) Transmission electron microscopy of an elongated microglial cell (m) with thin pseudopods in a naive ganglion. (d) Scanning electron microscopy of activated microglial cells accumulated at the lesions. Once recruited, the cells do progressively develop new ramifications (arrows). (Reprinted, with permission, from [31]).
