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Clinical and Developmental Immunology
Volume 2013 (2013), Article ID 281958, 14 pages
http://dx.doi.org/10.1155/2013/281958
Review Article

The Impact of the Myeloid Response to Radiation Therapy

1Earle A. Chiles Research Institute, Robert W. Franz Cancer Center, Providence Portland Medical Center, 4805 NE Glisan, Portland, OR 97213, USA
2The Department of Radiation Medicine, Oregon Health & Science University, Portland, OR 97239, USA
3The Oregon Clinic, Portland, OR 97213, USA

Received 31 January 2013; Revised 15 March 2013; Accepted 20 March 2013

Academic Editor: Luca Gattinoni

Copyright © 2013 Michael J. Gough et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Radiation therapy is showing potential as a partner for immunotherapies in preclinical cancer models and early clinical studies. As has been discussed elsewhere, radiation provides debulking, antigen and adjuvant release, and inflammatory targeting of effector cells to the treatment site, thereby assisting multiple critical checkpoints in antitumor adaptive immunity. Adaptive immunity is terminated by inflammatory resolution, an active process which ensures that inflammatory damage is repaired and tissue function is restored. We discuss how radiation therapy similarly triggers inflammation followed by repair, the consequences to adaptive immune responses in the treatment site, and how the myeloid response to radiation may impact immunotherapies designed to improve control of residual cancer cells.